Toward Imaging Biomarkers for Glycosaminoglycans

Gray, Martha L.

doi:10.2106/jbjs.h.01498

Cited by 15 publications

(14 citation statements)

References 22 publications

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“…In more recent studies, very much shorter periods of antibiotic treatment have been employed. Whittaker et al 44 reported a 92.7% eradication of infection for 41 re-implanted hip endoprostheses over a follow-up period of 4 years following a short, intravenous treatment with vancomycin alone in combination with cement spacers containing vancomycin and gentamicin. McKenna et al 45 only found one reinfection after an average of 35 month's follow-up of 30 patients with infected hip arthroplasties who as part of the two-stage revision procedure, only received a 5 day systemic treatment with antibiotics.…”

Section: Duration Of Antibiotic Treatmentmentioning

confidence: 99%

Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts

Fink¹

2009

Int. J. Med. Sci.

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Many concepts have been devised for the treatment of late periprosthetic infections of total hip prostheses. A two-stage revision with a temporary antibiotic-impregnated cement spacer and a cemented prosthesis appears to be the most preferred procedure although, in recent times, there seems to be a trend towards cementless implants and a shorter period of antibiotic treatment. Because of the differences in procedure, not only between studies but also within studies, it cannot be decided which period of parenteral antibiotic treatment and which spacer period is the most suitable. The fact that comparable rates of success can be achieved with different treatment regimens emphasises the importance of surgical removal of all foreign materials and the radical debridement of all infected and ischaemic tissues and the contribution of these crucial procedures to the successful treatment of late periprosthetic infections.

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Section: Duration Of Antibiotic Treatmentmentioning

confidence: 99%

Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts

Fink¹

2009

Int. J. Med. Sci.

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“…Recent editorials call for a thorough study of the T1ρ method and GAG content in human cartilage [31, 32] similar to the dGEMRIC method study by Bashir et al, which used biochemistry to measure GAG content [14]. If T1ρ relaxation time is correlated with GAG content in human cartilage, early detection of OA through a non-invasive, non-contrast-agent method may be possible.…”

Section: Introductionmentioning

confidence: 99%

Prediction of glycosaminoglycan content in human cartilage by age, T1ρ and T2 MRI

Keenan

Besier

Pauly

et al. 2011

Osteoarthritis and Cartilage

155

145

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Summary Objective A relationship between T1ρ relaxation time and glycosaminoglycan (GAG) content has been demonstrated in chemically degraded bovine cartilage, but has not been demonstrated with quantitative biochemistry in human cartilage. A relationship has also been established between T2 relaxation time in cartilage and osteoarthritis severity. We hypothesized that T1ρ relaxation time would be associated with GAG content in human cartilage with normal T2 relaxation times. Methods T2 relaxation time, T1ρ relaxation time, and glycosaminoglycan as a percentage of wet weight (sGAG) were measured for top and bottom regions at seven anatomical locations in twenty-one human cadaver patellae. For our analysis, T2 relaxation time was classified as normal or elevated based on a threshold defined by the mean plus one standard deviation of the T2 relaxation time for all samples. Results In the normal T2 relaxation time subset, T1ρ relaxation time correlated with sGAG in the full-thickness and bottom regions, but only marginally in the top region alone. sGAG decreased significantly with age in all regions. Conclusion In the subset of cartilage specimens with normal T2 relaxation time, T1ρ relaxation time was inversely associated with sGAG content, as hypothesized. A predictive model, which accounts for T2 relaxation time and the effects of age, might be able to determine longitudinal trends in GAG content in the same person based on T1ρ relaxation time maps.

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“…As they are the main source of fixed charge density 16 , their loss results in a major decrease in the compressive stiffness of cartilage 17 and has been associated with early cartilage degeneration 13 . In the dGEMRIC technique, the relative distribution of glycosaminoglycan is determined on MRI by measuring the longitudinal, or spin-lattice, relaxation rate (T1) following intravenous administration of gadopentate (Gd [DTPA] 22 , where DTPA is diethylene triamine pentaacetic acid) [17][18][19] . The anionic gadopentate molecule equilibrates inversely to the negatively charged glycosaminoglycan 13 .…”

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confidence: 99%

Temporal in Vivo Assessment of Fresh Osteochondral Allograft Transplants to the Distal Aspect of the Femur by dGEMRIC (Delayed Gadolinium-Enhanced MRI of Cartilage) and Zonal T2 Mapping MRI

Brown

Durkan²,

Foss

et al. 2014

Journal of Bone and Joint Surgery

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Functional MRI techniques can be applied to noninvasively assess the biochemical health of cartilage after osteochondral allograft transplantation. The MRI findings correlated with certain patient-reported outcomes in the early postoperative period. Relative glycosaminoglycan content and the collagen structure of allograft cartilage may undergo time-dependent degeneration. A patient's perception of clinical outcome and quality of life is likely multifactorial and is impacted by more than the health of the allograft cartilage.

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Toward Imaging Biomarkers for Glycosaminoglycans

Cited by 15 publications

References 22 publications

Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts

Revision of late periprosthetic infections of total hip endoprostheses: pros and cons of different concepts

Prediction of glycosaminoglycan content in human cartilage by age, T1ρ and T2 MRI

Temporal in Vivo Assessment of Fresh Osteochondral Allograft Transplants to the Distal Aspect of the Femur by dGEMRIC (Delayed Gadolinium-Enhanced MRI of Cartilage) and Zonal T2 Mapping MRI

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