Toward highly blood compatible hemodialysis membranes via blending with heparin-mimicking polyurethane: Study in vitro and in vivo

Ma, Lang; Su, Baihai; Cheng, Chong; Yin, Zehua; Qin, Hailong; Zhao, Jiayuan; Sun, Shudong; Zhao, Changsheng

doi:10.1016/j.memsci.2014.07.030

Cited by 84 publications

(47 citation statements)

References 65 publications

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“…Namun, membran kitosan mempunyai beberapa kelemahan, diantaranya: kurangnya sisi aktif, kekuatan mekanik yang rendah dan muatan positif pada permukaan membran. Penelitian sebelumnya [3,4] telah berhasil mendapatkan membran turunan kitosan melalui proses taut silang dengan gugus karboksilat yang digunakan pada proses transpor. Dikemukan bahwa turunan kitosan tersebut meningkatkan kemampuan transport dibanding dengan membran kitosan murni, karena gugus karboksilat berfungsi menjadi sisi aktif membran dalam proses penangkapan permeat.…”

Section: Pendahuluanunclassified

“…Untuk mengurangi muatan positif di permukaan membran kitosan [3,5] -. Gugus tersebut dimungkinkan dapat mengurangi sisi positif membran dan berfungsi sebagai sisi aktif membran.…”

Section: Pendahuluanunclassified

“…Keberhasilan immerse heparin pada membran kitosan, dibuktikan dengan uji FTIR pada Gambar 2. Data FTIR menunjukkan munculnya serapan pada daerah 870 cm-1 yang merupakan serapan gugus -SO3 dari heparin, sesuai dengan hasil [3].…”

Section: Membran Tercangkok Heparinunclassified

“…Hasil yang didapatkan menunjukkan bahwa membran CS.CAHep/PVA mempunyai persentase transpor paling tinggi. Hasil yang didapat sesuai dengan hasil yang didapatkan [3]. Hal ini dimungkinkan karena immerse heparin menambah sisi aktif pada membran…”

Section: Uji Serapan Air (Swelling)unclassified

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Pengaruh Agen Pencangkok Heparin terhadap Kemampuan Transpor Kreatinin dan Urea Membran Turunan Kitosan

2017

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A r t i c l e I n f oA b s t r a c t Keywords: immerse, heparin, transport percentageImmersion of heparin was performed on the chitosan membrane to add the membrane active side, to the urea transport process. From the analytical data, there was an increase of urea transport percentage from 17.57% to 27.09% with the addition of heparin. A b s t r a kKata kunci: immerse, heparin, persentase transporImmersi heparin dilakukan pada membran kitosan untuk menambah sisi aktif membran, pada proses transpor urea. Dari data analisis didapatkan terjadi peningkatan persentase transpor urea dari 17,57 % menjadi 27,09 % dengan adanya penambahan heparin.

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Section: Pendahuluanunclassified

“…Untuk mengurangi muatan positif di permukaan membran kitosan [3,5] -. Gugus tersebut dimungkinkan dapat mengurangi sisi positif membran dan berfungsi sebagai sisi aktif membran.…”

Section: Pendahuluanunclassified

Section: Membran Tercangkok Heparinunclassified

Section: Uji Serapan Air (Swelling)unclassified

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Pengaruh Agen Pencangkok Heparin terhadap Kemampuan Transpor Kreatinin dan Urea Membran Turunan Kitosan

2017

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“…The adsorption is mainly triggered by the electrostatic forces between charged reactive groups in the membrane with the opposite charge in blood protein. This will result in the decrease of membrane permeability which may lead to blood coagulation [8][9].…”

Section: Introductionmentioning

confidence: 99%

Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

2018

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Introduction of Nature's Complexity in Engineered Blood‐compatible Biomaterials

Ippel

Dankers

2017

Adv Healthcare Materials

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Biomaterials with excellent blood-compatibility are needed for applications in vascular replacement therapies, such as vascular grafts, heart valves and stents, and in extracorporeal devices such as hemodialysis machines and blood-storage bags. The modification of materials that are being used for blood-contacting devices has advanced from passive surface modifications to the design of more complex, smart biomaterials that respond to relevant stimuli from blood to counteract coagulation. Logically, the main source of inspiration for the design of new biomaterials has been the endogenous endothelium. Endothelial regulation of hemostasis is complex and involves a delicate interplay of structural components and feedback mechanisms. Thus, challenges to develop new strategies for blood-compatible biomaterials now lie in incorporating true feedback controlled mechanisms that can regulate blood compatibility in a dynamic way. Here, supramolecular material systems are highlighted as they provide a promising platform to introduce dynamic reciprocity, due to their inherent dynamic nature.

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Toward highly blood compatible hemodialysis membranes via blending with heparin-mimicking polyurethane: Study in vitro and in vivo

Cited by 84 publications

References 65 publications

Pengaruh Agen Pencangkok Heparin terhadap Kemampuan Transpor Kreatinin dan Urea Membran Turunan Kitosan

Pengaruh Agen Pencangkok Heparin terhadap Kemampuan Transpor Kreatinin dan Urea Membran Turunan Kitosan

Preparation of Citric Acid Crosslinked Chitosan/Poly(Vinyl Alcohol) Blend Membranes for Creatinine Transport

Introduction of Nature's Complexity in Engineered Blood‐compatible Biomaterials

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