Toward Glycomaterials with Selectivity as Well as Affinity

Richards, Sarah‐Jane; Gibson, Matthew I.

doi:10.1021/jacsau.1c00352

Cited by 21 publications

(24 citation statements)

References 128 publications

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“…It is important to note that beyond multivalency/presentation on polymeric scaffolds, glycan arrays have allowed the probing of multi-antennary/branched glycans. 156 The benefits of this approach are well illustrated by Wang et al, who synthesised a series of asymmetrically substituted multiantennary glycans and found differential binding between the structures despite presenting similar terminal sugars. 157…”

Section: Structural and Synthetic Strategies For Glycan Presentationmentioning

confidence: 99%

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

et al. 2022

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Section: Structural and Synthetic Strategies For Glycan Presentationmentioning

confidence: 99%

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

et al. 2022

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“…100,101 So far, heteroglycopolymers have mainly been studied not only as a way of increasing the strength of binding with soluble lectins but also to enhance the selectivity of the lectin binding process. 101 While these heteroglycopolymers have not yet been used for drug delivery, it was shown that copolymers prepared from two glycomonomers can enhance binding to cells, which is discussed in the next section. 98 ■ GLYCOPOLYMERS FOR TARGETED CELLULAR UPTAKE Valuable lessons were learned when monitoring binding between soluble lectins and glycopolymers of various structures (Figure 6).…”

Section: ■ Lectin Bindingmentioning

confidence: 99%

“…A recent perspective article discussed the possibility of improving affinity of glycomaterials as well as selectivity by modifying the glycan architecture. 101 Careful fine-tuning of structural features can improve selectivity toward specific lectins while binding strength is not jeopardized. While this has not yet been explored in a drug delivery scenario, studies on glycopolymers and soluble lectins confirm that this is an approach worth pursuing.…”

Section: ■ Conclusion and Outlookmentioning

confidence: 99%

Glycopolymers for Drug Delivery: Opportunities and Challenges

Stenzel

2022

Macromolecules

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Glycopolymers are synthetic polymers with pendant sugars, which hold promise for a range of biomedical applications ranging from tissue engineering to sensing. The known specific interaction of glycopolymers with lectins has inspired researchers to use these polymers to deliver drugs to cells that overexpress lectin receptors. As a result, many glycopolymersbased on mannose, galactose, fructose, or other saccharides−have been used for the targeted delivery of drugs, ranging from traditional anticancer drugs to nucleic acid-derived therapeutics. For drug delivery purposes, glycopolymers are typically processed into nanoparticles that form a matrix to entrap the drug safely, such as micelles, polyplexes, polyion complex micelles, or other nanosized carriers. In vitro and in vivo studies have shown that drugs can indeed be delivered selectively to specific cells by leveraging the selective recognition of surface bound lectins. The key to the interaction between glycopolymers and lectins is the presence of strong intermolecular forces such as hydrogen bonding. The formation of strong hydrogen bonds can, however, also be one of the drawbacks of these materials. Glycopolymers tend to self-aggregate, they interact with drugs in unexpected ways, or they bind proteins in a nonspecific manner. Despite these challenges, nanoparticles based on glycopolymers might offer possibilities that cannot be replicated by other watersoluble polymers. They have already shown that they can effectively deliver drugs in vivo, though more preclinical studies are necessary to enable their broader clinical uptake. Further focus could be directed at an improved understanding of the interface between glycopolymers and the biological surrounding as a key to improve the targeting ability of these nanoparticles in vivo. In this Perspective, I will discuss the aspects to consider when preparing drug delivery carrier using glycopolymers. This will include the interaction of the glyconanoparticles with the drug and the resulting property changes, the types of glycopolymers suitable for drug delivery, the effect of the nanoparticle structure on the affinity to cell surface bound lectins or GLUT transporters and the promising in vivo results that show selective delivery.

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“…[ 19 ] Several complications obstruct the study of native mucins and our ability to exploit their properties for biomedical or engineering applications, thus motivating the synthesis of mucin analogs or mucin‐mimic polymers. [ 20,21 ] Mucin needs to be harvested while ensuring its function away from epithelium. Furthermore, native mucins suffer from variable glycosylation causing high batch‐to‐batch variability.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Bayer

2022

Adv Materials Inter

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Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways. Mucin is the key polymeric compound that is known as a family of high molecular weight, heavily glycosylated proteins in epithelial tissues. Mucoadhesion can occur in many different ways such as receptor specific and charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers that replicate its beneficial traits can prevent biofilm formation and biofouling not only in biotechnology but also in membrane technologies. This review addresses the latest understandings related to mucin's role in wet adhesion considering different physiological conditions and shows how this translates into interfacial polymer adhesion. Advances in mucoadhesion measurement techniques including the rheological aspects of polymer–mucin adhesive interactions are presented. Specific mucoadhesive systems are discussed such as hydrogel mucoadhesion, catechol/dopamine functionalization, and polymeric nanoparticles. This overview may expand the current understanding of mucoadhesion between soft materials but also contributes to elastocapillary phenomena in soft materials design and applications such as new membranes, drugs, pharmaceutical devices, and lubricated surfaces.

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Toward Glycomaterials with Selectivity as Well as Affinity

Cited by 21 publications

References 128 publications

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Glycosylated gold nanoparticles in point of care diagnostics: from aggregation to lateral flow

Glycopolymers for Drug Delivery: Opportunities and Challenges

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

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