Toward failure analyses in systems biology

Bhattacharya, Sanjoy K.; Gomes, James; Cebulla, Colleen M.

doi:10.1002/wsbm.83

Cited by 2 publications

(1 citation statement)

References 55 publications

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“…a set of proteins capable of independent functionality) and networks. The difficulty in drawing contours and boundaries of signaling pathways becomes more evident when the study of the system is approached with formal engineering failure analysis [25] . Systems biology approaches may provide crucial clues about the architecture and the logic of the regulation of the NF-κB system and related gene expression [20] .…”

Section: Introductionmentioning

confidence: 99%

Charting the NF-κB Pathway Interactome Map

et al. 2012

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Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-κB activation, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of the present analysis is to provide a wider, systemic picture of the NF-κB signaling system. Data from different sources such as literature, functional enrichment web resources, protein-protein interaction and pathway databases have been gathered, curated, integrated and analyzed in order to reconstruct a single, comprehensive picture of the proteins that interact with, and participate to the NF-κB activation system. Such a reconstruction shows that the NF-κB interactome is substantially different in quantity and quality of components with respect to canonical representations. The analysis highlights that several neglected but topologically central proteins may play a role in the activation of NF-κB mediated responses. Moreover the interactome structure fits with the characteristics of a bow tie architecture. This interactome is intended as an open network resource available for further development, refinement and analysis.

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Section: Introductionmentioning

confidence: 99%

Charting the NF-κB Pathway Interactome Map

et al. 2012

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Charting the NF-kB pathway interactome map

et al. 2010

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One of the phenomena observed in human aging is the progressive increase of a systemic inflammatory state, a condition referred to as “inflammaging”, negatively correlated with longevity. The five components of the Nuclear Factor kB (NF-kB) family are prominent mediators of inflammation. Several different signaling pathways activated by very diverse stimuli converge on NF-kB, resulting in a regulatory system characterized by high complexity. It is increasingly recognized that the number of components that impinges upon phenotypic outcomes of signal transduction pathways may be higher than those taken into consideration from canonical pathway representations. Scope of this analysis is to provide a wider, systemic picture of such intricate signaling system.

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Toward failure analyses in systems biology

Cited by 2 publications

References 55 publications

Charting the NF-κB Pathway Interactome Map

Charting the NF-κB Pathway Interactome Map

Charting the NF-kB pathway interactome map

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