Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review

Tanskanen, Jarno M. A.; Ahtiainen, Annika; Hyttinen, Jari

doi:10.1089/bioe.2020.0028

Cited by 9 publications

(8 citation statements)

References 176 publications

(187 reference statements)

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“…Real-time, multi-channel EEG data can be used to monitor the brain state online and modify stimulation parameters 68 to apply state-dependent brain stimulation. EEG can also be used to design closed-loop, purpose-driven stimuli, to provide brain-state guided stimulation 69 , 70 .…”

Section: Discussionmentioning

confidence: 99%

Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation

Chen

Hendee

2022

Sci Rep

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Novel stimulation protocols for neuromodulation with magnetic fields are explored in clinical and laboratory settings. Recent evidence suggests that the activation state of the nervous system plays a significant role in the outcome of magnetic stimulation, but the underlying cellular and molecular mechanisms of state-dependency have not been completely investigated. We recently reported that high frequency magnetic stimulation could inhibit neural activity when the neuron was in a low active state. In this paper, we investigate state-dependent neural modulation by applying a magnetic field to single neurons, using the novel micro-coil technology. High frequency magnetic stimulation suppressed single neuron activity in a state-dependent manner. It inhibited neurons in slow-firing states, but spared neurons from fast-firing states, when the same magnetic stimuli were applied. Using a multi-compartment NEURON model, we found that dynamics of voltage-dependent sodium and potassium channels were significantly altered by the magnetic stimulation in the slow-firing neurons, but not in the fast-firing neurons. Variability in neural activity should be monitored and explored to optimize the outcome of magnetic stimulation in basic laboratory research and clinical practice. If selective stimulation can be programmed to match the appropriate neural state, prosthetic implants and brain-machine interfaces can be designed based on these concepts to achieve optimal results.

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Section: Discussionmentioning

confidence: 99%

Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation

Chen

Hendee

2022

Sci Rep

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“…These features are commonly investigated using, e.g., brain slices or cultures of primary rodent cells, as well as human induced pluripotent stem cells. Therefore, the neuronal extracellular activity is often recorded with microelectrode array (MEA) measurements [ 23 , 24 , 25 ]. MEA electrodes record extracellular potentials of neurons or neuronal populations in the vicinity of the electrodes.…”

Section: Introductionmentioning

confidence: 99%

Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures

Ahtiainen

Genocchi

Tanskanen

et al. 2021

IJMS

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Astrocytes and neurons respond to each other by releasing transmitters, such as γ-aminobutyric acid (GABA) and glutamate, that modulate the synaptic transmission and electrochemical behavior of both cell types. Astrocytes also maintain neuronal homeostasis by clearing neurotransmitters from the extracellular space. These astrocytic actions are altered in diseases involving malfunction of neurons, e.g., in epilepsy, Alzheimer’s disease, and Parkinson’s disease. Convulsant drugs such as 4-aminopyridine (4-AP) and gabazine are commonly used to study epilepsy in vitro. In this study, we aim to assess the modulatory roles of astrocytes during epileptic-like conditions and in compensating drug-elicited hyperactivity. We plated rat cortical neurons and astrocytes with different ratios on microelectrode arrays, induced seizures with 4-AP and gabazine, and recorded the evoked neuronal activity. Our results indicated that astrocytes effectively counteracted the effect of 4-AP during stimulation. Gabazine, instead, induced neuronal hyperactivity and synchronicity in all cultures. Furthermore, our results showed that the response time to the drugs increased with an increasing number of astrocytes in the co-cultures. To the best of our knowledge, our study is the first that shows the critical modulatory role of astrocytes in 4-AP and gabazine-induced discharges and highlights the importance of considering different proportions of cells in the cultures.

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“…Fernando Novio 1,2 , Julia Lorenzo 3,4 and Daniel Ruiz-Molina 1 1 CSIC and BIST, Campus UAB, Catalan Institute of Nanoscience and Nanotechnology (ICN2), Barcelona, Spain 2 Departament de Química, Universitat Autònoma de Barcelona, Barcelona, Spain 3 Institut de Biotecnologia i Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain 4 Departament de Bioquímica i Biologia Molecular, Universitat Autònoma de Barcelona, Barcelona, Spain…”

Section: Nanoparticles-based Developments For Parkinson's Disease Tre...unclassified

Roadmap on nanomedicine for the central nervous system

et al. 2023

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In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier (BBB) acts as a obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the central nervous system one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the central nervous system.

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Toward Closed-Loop Electrical Stimulation of Neuronal Systems: A Review

Cited by 9 publications

References 176 publications

Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation

Cellular mechanisms underlying state-dependent neural inhibition with magnetic stimulation

Astrocytes Exhibit a Protective Role in Neuronal Firing Patterns under Chemically Induced Seizures in Neuron–Astrocyte Co-Cultures

Roadmap on nanomedicine for the central nervous system

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