Toward carbon nanotube-based imaging agents for the clinic

Hernández‐Rivera, Mayra; Zaibaq, Nicholas G.; Wilson, Lon J.

doi:10.1016/j.biomaterials.2016.05.045

Cited by 46 publications

(29 citation statements)

References 126 publications

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“…Engineered CNTs are able to act as excellent adjuvant Contrast Agents (CA) for many different imaging techniques [42] and to enhance drug cytotoxicity [43]. Moreover, they can be used to perform thermal ablation [44], as well as to detect Reactive Oxygen Species (ROS) [45] or specific antigens, likewise tumor markers [46].…”

Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation. Nevertheless, deep investigations about carbon nanotubes’ potential bio-compatibility and cytotoxicity limits should be also critically addressed. In the present review, after introducing carbon nanotubes and their promising advantages and drawbacks for fighting cancer, we want to focus on the numerous and different ways in which they can assist to reach this goal. Specifically, we report on how they can be used not only for drug delivery purposes, but also as a powerful ally to develop effective contrast agents for tumors’ medical or photodynamic imaging, to perform direct physical ablation of metastasis, as well as gene therapy.

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Section: Cnts and Cancermentioning

confidence: 99%

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

2017

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“…19,20 SWCNTs exhibit photostable, intrinsic photoluminescence in the near infrared (NIR) spectral window 21 where there is minimal absorption, autofluorescence, and scattering of light in biological specimens. 22 Therefore, SWCNTs are promising for the study of cellular transport processes.…”

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confidence: 99%

A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway

et al. 2017

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Single-walled carbon nanotubes are of interest in biomedicine for imaging and molecular sensing applications, and as shuttles for various cargos such as chemotherapeutic drugs, peptides, proteins, and oligonucleotides. Carbon nanotube surface chemistry can be modulated for subcellular targeting while preserving photoluminescence for label-free visualization in complex biological environments, making them attractive materials for such studies. The cell nucleus is a potential target for many pathologies including cancer and infectious diseases. Understanding mechanisms of nanomaterial delivery to the nucleus may facilitate diagnostics, drug development, and gene editing tools. Currently, there are no systematic studies to understand how these nanomaterials gain access to the nucleus. Herein, we developed carbon nanotube-based hybrid material which elucidated a distinct mechanism of nuclear translocation of a nanomaterial in cultured cells. We developed a nuclear-targeted nanotube via cloaking photoluminescent single-walled carbon nanotubes in a guanidinium-functionalized helical polycarbodiimide. We found that the nuclear entry of the nanotubes was mediated by the import receptor importin β without the aid of importin α and not by the more common importin α/β pathway. Additionally, the nanotube photoluminescence exhibited distinct red-shifting upon entry to the nucleus, potentially functioning as a reporter of the importin β-mediated nuclear transport process. This work delineates a non-canonical mechanism for nanomaterial delivery to the nucleus and provides a reporter for the study of nucleus-related pathologies.

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“…Carbon nanomaterials have been found to be an excellent scaffold for contrast agents since they can be used to carry imaging agents, such as fluorescent labels and radionuclides, contributing to the generation of high-quality images and the early detection of breast cancer [20,21,49,[56][57][58]. Experiments have demonstrated that CNT can carry imaging agents [57] and demonstrated great potential of using functionalized MWCNT as efficient cell probes for MRI [59].…”

Section: Contrast Agentmentioning

confidence: 99%

“…Experiments have demonstrated that CNT can carry imaging agents [57] and demonstrated great potential of using functionalized MWCNT as efficient cell probes for MRI [59]. In vivo MRI on mice showed that CNTs functionalized with Gd (GdCNTs) have the ability to act as a good contrast agent [60].…”

Section: Contrast Agentmentioning

confidence: 99%

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Carbon Nanomaterials for Breast Cancer Treatment

Casais-Molina

Cab

Canto

et al. 2018

Journal of Nanomaterials

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Currently, breast cancer is considered as a health problem worldwide. Furthermore, current treatments neither are capable of stopping its propagation and/or recurrence nor are specific for cancer cells. Therefore, side effects on healthy tissues and cells are common. An increase in the efficiency of treatments, along with a reduction in their toxicity, is desirable to improve the life quality of patients affected by breast cancer. Nanotechnology offers new alternatives for the design and synthesis of nanomaterials that can be used in the identification, diagnosis, and treatment of cancer and has now become a very promising tool for its use against this disease. Among the wide variety of nanomaterials, the scientific community is particularly interested in carbon nanomaterials (fullerenes, nanotubes, and graphene) due to their physical properties, versatile chemical functionalization, and biocompatibility. Recent scientific evidence shows the potential uses of carbon nanomaterials as therapeutic agents, systems for selective and controlled drug release, and contrast agents for diagnosing and locating tumors. This generates new possibilities for the development of innovative systems to treat breast cancer and can be used to detect this disease at much earlier stages. Thus, applications of carbon nanomaterials in breast cancer treatment are discussed in this article.

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Toward carbon nanotube-based imaging agents for the clinic

Cited by 46 publications

References 126 publications

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment

A Carbon Nanotube Optical Sensor Reports Nuclear Entry via a Noncanonical Pathway

Carbon Nanomaterials for Breast Cancer Treatment

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