Toward an integrative model of transdiagnostic risk factors and suicide: A network comparison of psychiatric outpatients

Karnick, Aleksandr T.; Fergerson, Ava K.; Caulfield, Nicole M.; Buerke, Morgan; Albanese, Brian J.; Schmidt, Norman B.; Capron, Daniel W.

doi:10.1016/j.jpsychires.2022.07.050

Cited by 3 publications

(3 citation statements)

References 79 publications

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“…For example, Wang and Eaton [2] found that transdiagnostic dimensions were superior to common DSM-IV and DSM-5 diagnoses in predicting NSSI, accounting for 33.6-38.7% of the variance in NSSI across the sample. These recent findings on NSSI are consistent with data on suicidal 2 of 15 behavior, which may also exist across diagnostic boundaries, since suicide-related variables are more strongly associated with the shared variance of multiple mental disorders than with their unique disorder-specific variances [3,4].…”

Section: Introductionsupporting

confidence: 85%

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-Suicidal Self-Injury in Females with Non-Psychotic Mental Disorders and Suicidal Ideation

Zinchuk,

Druzhkova,

Popova

et al. 2023

Biomedicines

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Nonsuicidal self-injurious behavior (NSSI), prevalent in patients with non-psychotic mental disorders (NPMD), is associated with numerous adverse outcomes. Despite active research into the clinical and psychological aspects of NSSI, the underlying biological mechanisms remain obscure. Early adverse experiences are believed to induce long-lasting changes in neuroendocrine mechanisms of stress control playing a key role in NSSI development. The aim of the study was to evaluate parameters potentially predicting development of NSSI in female patients with NPMD and suicidal ideation. Eighty female patients over 18 years with NPMD and suicidal ideation (40 with and 40 without NSSI) and 48 age matching women without evidence of mental illness (healthy controls) were enrolled. Diagnostic interviews and self-report measures were used to assess childhood maltreatment, presence, frequency, and characteristics of suicidal and self-injurious thoughts and behaviors, the Beck Depression Inventory scale to assess severity of depression. Hypothalamic-pituitary-adrenal axis markers, hormones, and neurotrophic factors were measured in blood serum. The likelihood of developing NSSI in patients with NPMD and suicidal ideation was associated with early adverse family history and elevated adrenocorticotropic hormone levels. Dysregulation of hypothalamic-pituitary-adrenal axis as a result of early chronic stress experiences may represent critical biological mechanism promoting the development of NSSI behaviors in patients with NPMD.

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Section: Introductionsupporting

confidence: 85%

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-Suicidal Self-Injury in Females with Non-Psychotic Mental Disorders and Suicidal Ideation

Zinchuk,

Druzhkova,

Popova

et al. 2023

Biomedicines

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“…Against our hypothesis, the high schizotypy group did not demonstrate a stronger network structure than the low schizotypy group. While our hypothesis was based on previous findings [ 33 ] and the hysteresis principle of network theory [ 37 ], works suggesting stronger network structures in groups with psychopathology have largely examined networks with larger constructs as nodes [ 68 , 69 ]. This same phenomenon of stronger networks may not hold for item-level networks of one very specific aspect of social functioning (i.e., empathy), where the hysteresis principle of network theory stating that symptoms exacerbate one another may be less applicable.…”

Section: Discussionmentioning

confidence: 99%

Empathy and Schizotypy: A Network Comparison of the Interpersonal Reactivity Index in High and Low Schizotypy Groups

Hammer,

Karnick,

Beals

et al. 2024

Behavioral Sciences

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Empathy is a multifaceted concept that is vital to effective social functioning; yet, it is impaired in high schizotypy groups. Furthermore, empathy has been found to be a mediator in the relationship between schizotypy and social functioning, highlighting the importance of empathy as a driver in social outcomes. Despite this, the four-factor structure of a widely-used measure of empathy—the Interpersonal Reactivity Index (IRI)—has been found to be psychometrically weak in high schizotypy samples. As such, this study aimed to assess differences in the item-level network of the IRI between high (n = 427) and low schizotypy groups (n = 470). The results reveal that there are significant differences in the structure of these networks, though they evidence similar strengths. Within the high schizotypy group, the network structure was consistent with the four-factor structure of the IRI subscales; items from each subscale clustered together and were distinct from those in the other subscales. By contrast, the low schizotypy group evidenced six clusters that did not mirror the IRI subscales. These results suggest that the item-level structure of the IRI is dependent upon the level of schizotypy of the sample, with the high schizotypy group’s network functioning similarly to what would be expected from the original four-factor structure.

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“…If quantitative accumulation on this topic is premised in the future, it may be possible to investigate the effectiveness of acupuncture on suicidal behavior in specific clinical conditions, such as major depression. However, it should be noted that suicidal behavior still has transdiagnostic characteristics [ 58 ]. Second, the methodological quality of the included studies was suboptimal.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness and Safety of Acupuncture on Suicidal Behavior: A Systematic Review

Kwon

Lee

2023

Healthcare

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In situations where death by suicide is a major global issue and effective prevention and management approaches are lacking, acupuncture improves some risk factors for suicide, including depression, and it has been used for a long time in clinical settings. Herein, we aimed to assess the effectiveness and safety of acupuncture in the treatment of suicidal behaviors. Fourteen electronic databases were searched for studies published up to 7 September 2022. Original interventional studies of acupuncture in suicide prevention were included. The primary outcome was the validated measure of suicidal ideation. The risk of bias in the included studies was assessed using an appropriate assessment tool. Due to the heterogeneity of the included studies, only qualitative analyses were conducted. Eight studies on manual acupuncture (50%), electro-acupuncture (37.5%), and acupressure (12.5%) were included. In particular, three studies (37.5%) used the National Acupuncture Detoxification Association protocol to stimulate the bilateral sympathetic, Shenmen, kidney, liver, and lung auricular points. Acupuncture was effective in direct and indirect outcomes related to suicidal behavior, not only for participants with suicidal behavior, but also for those with other conditions, including depression. A decrease in salivary cortisol was the only biological indicator of acupuncture in patients with suicidal ideation. However, the methodological quality of the included studies was not optimal. In conclusion, acupuncture may reduce the risk of suicidal behavior in clinical and non-clinical populations. Owing to clinical heterogeneity, low methodological quality, and the small number of included studies, further high-quality studies should assess the effectiveness of acupuncture.

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Toward an integrative model of transdiagnostic risk factors and suicide: A network comparison of psychiatric outpatients

Cited by 3 publications

References 79 publications

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-Suicidal Self-Injury in Females with Non-Psychotic Mental Disorders and Suicidal Ideation

Early Adverse Family Experiences and Elevated Adrenocorticotropic Hormone Predict Non-Suicidal Self-Injury in Females with Non-Psychotic Mental Disorders and Suicidal Ideation

Empathy and Schizotypy: A Network Comparison of the Interpersonal Reactivity Index in High and Low Schizotypy Groups

The Effectiveness and Safety of Acupuncture on Suicidal Behavior: A Systematic Review

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