Toward a rodent model of the Iowa gambling task

Bos, Ruud van den; Lasthuis, Wilma; Heijer, Esther den; Harst, Johanneke van der; Spruijt, Berry M.

doi:10.3758/bf03192801

Cited by 84 publications

(76 citation statements)

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“…We are currently undertaking neuroimaging studies to bridge the gap between the species. Furthermore, we only studied female subjects, because female human subjects and female rats tend to choose more often long-term disadvantageous options in the IGT than male counterparts (Reavis and Overman, 2001; Van den Bos et al, 2006b, 2007; but see Overman, 2004), leaving only limited opportunity to detect any improvements in IGT performance. Interestingly, in a small pilot study SERT þ/þ and SERT À/À male rats performed the task equally well.…”

Section: Discussionmentioning

confidence: 99%

“…To compare the rat data to the human data, the difference score was divided by 3. The choices for the empty arms were analyzed as proportion of empty arm visits per block of 10 trials (Van den Bos et al, 2006b). …”

Section: Iowa Gambling Task In Female Sert Knockout Ratsmentioning

confidence: 99%

“…The Iowa Gambling Task was performed as described previously (Van den Bos et al, 2006b) with minor modifications. In short, food restricted rats (95 AE 5% free feeding body weight) were tested between 10.00 am and 16.00 pm.…”

Section: Iowa Gambling Task In Female Sert Knockout Ratsmentioning

confidence: 99%

“…We argue here that this information can be used to understand the mechanisms underlying 5-HTTLPR phenotypes, if comparable tests in rodents and humans are used. The availability of a rodent version of the IGT makes this possible ( Van den Bos et al, 2006b). In this study we used the novel SERT homozygous (SERT À/À ) and heterozygous (SERT þ/À ) rat knockout model (Smits et al, 2006), for which we know that extra-neuronal 5-HT levels are gene-dose dependently increased (Homberg et al, 2007a; J.H., E.C., unpublished observations).…”

Section: Introductionmentioning

confidence: 99%

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Serotonin transporter dosage modulates long-term decision-making in rat and human

et al. 2008

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a b s t r a c tDecision-making plays an important role in everyday life and is often disturbed in psychiatric conditions affected by the common human serotonin transporter promoter length polymorphism (5-HTTLPR). This raises the hypothesis that decision-making is modulated by the serotonergic system, but currently it is unclear how the 5-HTTLPR affects central serotonergic functioning. We tested healthy human volunteers genotyped for the 5-HTTLPR in the Iowa Gambling Task (IGT), which is one of the most frequently used neuropsychological tasks to assess decision-making. Furthermore, we tested female homozygous (SERT À/À ) and heterozygous (SERT þ/À ) serotonin transporter knockout rats in a rodent version of the IGT.Women homozygous for the short (s) allele of the 5-HTTLPR were found to choose more disadvantageously than women homozygous for the long allele of the 5-HTTLPR as the IGT progressed. In the rat, SERT À/À and SERT þ/À were associated with advantageous decision-making compared to SERT þ/þ as the IGT progressed. Combining the human and rat observations, we show that SERT dosage affects the maintenance of a once established choice option, irrespective of the choice (advantageous or disadvantageous) that has been made. We postulate that the SERT-mediated effects relate to deficits in the processing of choice outcome to guide subsequent choices in this gamble-based test, and that SERT À/À and SERT þ/À rodent models in combination with studies in humans can be used to provide insight in the modulatory effects of 5-HTTLPR.

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Section: Discussionmentioning

confidence: 99%

Section: Iowa Gambling Task In Female Sert Knockout Ratsmentioning

confidence: 99%

Section: Iowa Gambling Task In Female Sert Knockout Ratsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serotonin transporter dosage modulates long-term decision-making in rat and human

et al. 2008

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“…Indeed, the cognitive mechanisms required for above-chance performance may not even be exclusive to humans. Van den Bos, Lasthuis, den Heijer, Van der Harst and Spruijt (2006) produced a rodent version of the IGT tested on both mice and rats and found that the participant performance followed a developmental trajectory similar to that of the human participants on the IGT (see also Zeeb, Robbins and Winstanley 2009 for reported results on another recent rat-based IGT variant). Of course, it may be challenged that rather than highlighting the limitations of the IGT as a sufficiently complex cognitive task, the findings say more about the extent to which rat cognitive capabilities are underestimated with respect to humans.…”

Section: The Issue Of Methodological Criticismmentioning

confidence: 89%

Towards a cognitive robotics methodology for reward-based decision-making: dynamical systems modelling of the Iowa Gambling Task

Lowe

Ziemke

2010

Connection Science

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The somatic marker hypothesis (SMH) posits that the role of emotions and mental states in decision-making manifests through bodily responses to stimuli of import to the organism's welfare. The Iowa Gambling Task (IGT), proposed by Bechara and Damasio in the mid-1990s, has provided the major source of empirical validation to the role of somatic markers in the service of flexible and cost-effective decision-making in humans. In recent years the IGT has been the subject of much criticism concerning: (1) whether measures of somatic markers reveal that they are important for decision-making as opposed to behaviour preparation;(2) the underlying neural substrate posited as critical to decision-making of the type relevant to the task; and (3) aspects of the methodological approach used, particularly on the canonical version of the task. In this paper, a cognitive robotics methodology is proposed to explore a dynamical systems approach as it applies to the neural computation of reward-based learning and issues concerning embodiment. This approach is particularly relevant in light of a strongly emerging alternative hypothesis to the SMH, the reversal learning hypothesis, which links, behaviourally and neurocomputationally, a number of more or less complex reward-based decision-making tasks, including the 'A-not-B' task -already subject to dynamical systems investigations with a focus on neural activation dynamics. It is also suggested that the cognitive robotics methodology may be used to extend systematically the IGT benchmark to more naturalised, but nevertheless controlled, settings that might better explore the extent to which the SMH, and somatic states per se, impact on complex decision-making.

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Translational Models of Gambling-Related Decision-Making

Winstanley

Clark

2015

Translational Neuropsychopharmacology

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Toward a rodent model of the Iowa gambling task

Cited by 84 publications

References 32 publications

Serotonin transporter dosage modulates long-term decision-making in rat and human

Serotonin transporter dosage modulates long-term decision-making in rat and human

Towards a cognitive robotics methodology for reward-based decision-making: dynamical systems modelling of the Iowa Gambling Task

Translational Models of Gambling-Related Decision-Making

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