Toward a chronophysiology of circulating aldosterone

Cugini, P; Centanni, Marco; Murano, G; Letizia, Claudio; Lucia, P; Scavo, D; Halberg, Franz; Sothern, Robert B.; Cornélissen, Germaine

doi:10.1016/0006-2944(84)90080-2

Cited by 6 publications

(4 citation statements)

References 21 publications

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“…Previous studies were performed either in men only or in both genders without consideration of gender differences. The only study referring the comparison of circadian rhythm of plasma aldosterone between healthy men and women failed to find any significant gender differences 53 . In the present studies, a sexual dimorphism in salivary aldosterone concentrations was observed in the morning but not in the evening (Fig.…”

Section: Salivary Aldosteronecontrasting

confidence: 42%

Endocrine Factors in Stress and Psychiatric Disorders

Ježová

Hlavacova

2008

Annals of the New York Academy of Sciences

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Glucocorticoids and other steroids produced in the adrenal cortex are altered in chronic stress situations associated with enhanced anxiety. A useful tool to evaluate changes in adrenal steroids during stress and anxiety under both laboratory and real-life stress situations is determination of steroids in saliva. The main advantages of this technique are its noninvasiveness and its measurement of biologically active free hormone levels. Salivary cortisol is a valuable indicator of the activity of the hypothalamic-pituitary-adrenocortical axis, which is known to be altered in psychiatric disorders. Measurements of salivary cortisol helped to reveal changes that would otherwise remained undetected, such as increase in cortisol release in spontaneously occurring panic attacks. By selecting only the subjects with high and low trait anxiety, we have brought evidence confirmed by others that high trait anxiety may be associated with an inability to respond with adequate cortisol release during stress. Papers on the relationship between salivary dehydroepiandrosterone and trait anxiety or anxiety disorders are rare, and this stress hormone deserves more attention. Almost nothing is known on aldosterone and anxiety. We have modified the methodology of aldosterone radioimmunoassay by concentrating the saliva and validated it biologically by demonstrating daily variation and gender differences. We have provided the first data on the relationship between aldosterone and trait anxiety. Obtained results show a significant negative correlation between morning salivary aldosterone concentrations and trait anxiety scores in women (luteal phase), but not in men. A more proper elucidation of the association between aldosterone and anxiety seems to be an important target of further research.

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Section: Salivary Aldosteronecontrasting

confidence: 42%

Endocrine Factors in Stress and Psychiatric Disorders

Ježová

Hlavacova

2008

Annals of the New York Academy of Sciences

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“…Plasma aldosterone secretion is synchronized with that of CORT in human and rats ( Hilfenhaus, 1976 ; Ryoyu et al, 1984 ; Cugini et al, 1992 ). With old age (∼80 years), there is a decrease in plasma aldosterone levels ( Cugini et al, 1984 ) and also there is a consistent decrease in circadian amplitude in women but not in men.…”

Section: Circulating Steroids and Their Fluctuationsmentioning

confidence: 99%

Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

Yao

Silver

2022

Front. Behav. Neurosci.

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BackgroundSteroids are lipid hormones that reach bodily tissues through the systemic circulation, and play a major role in reproduction, metabolism, and homeostasis. All of these functions and steroids themselves are under the regulation of the circadian timing system (CTS) and its cellular/molecular underpinnings. In health, cells throughout the body coordinate their daily activities to optimize responses to signals from the CTS and steroids. Misalignment of responses to these signals produces dysfunction and underlies many pathologies.Questions AddressedTo explore relationships between the CTS and circulating steroids, we examine the brain clock located in the suprachiasmatic nucleus (SCN), the daily fluctuations in plasma steroids, the mechanisms producing regularly recurring fluctuations, and the actions of steroids on their receptors within the SCN. The goal is to understand the relationship between temporal control of steroid secretion and how rhythmic changes in steroids impact the SCN, which in turn modulate behavior and physiology.Evidence SurveyedThe CTS is a multi-level organization producing recurrent feedback loops that operate on several time scales. We review the evidence showing that the CTS modulates the timing of secretions from the level of the hypothalamus to the steroidogenic gonadal and adrenal glands, and at specific sites within steroidogenic pathways. The SCN determines the timing of steroid hormones that then act on their cognate receptors within the brain clock. In addition, some compartments of the body-wide CTS are impacted by signals derived from food, stress, exercise etc. These in turn act on steroidogenesis to either align or misalign CTS oscillators. Finally this review provides a comprehensive exploration of the broad contribution of steroid receptors in the SCN and how these receptors in turn impact peripheral responses.ConclusionThe hypothesis emerging from the recognition of steroid receptors in the SCN is that mutual shaping of responses occurs between the brain clock and fluctuating plasma steroid levels.

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“…This permits variations in salt and water output caused by reninangiotensin-aldosterone activity due to posture, which are normally modified by the diurnal rhythm, 10 to become dominant. During the day, the relative inability to excrete a waterload in the upright position 9 causes fluid retention, whilst at night there is a high output of sodium and water due to low aldosterone levels 11 and volume expansion with increased plasma natriuretic peptide concentrations 12 resulting from resorption of fluid from the legs when lying flat in bed.…”

Section: 7mentioning

confidence: 99%

Letter to the Editor

Bliss

1998

Rev. Clin. Gerontol.

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Toward a chronophysiology of circulating aldosterone

Cited by 6 publications

References 21 publications

Endocrine Factors in Stress and Psychiatric Disorders

Endocrine Factors in Stress and Psychiatric Disorders

Mutual Shaping of Circadian Body-Wide Synchronization by the Suprachiasmatic Nucleus and Circulating Steroids

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