Toward 19F magnetic resonance thermometry: spin–lattice and spin–spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

Prinz, Christian; Delgado, Paula Ramos; Eigentler, Thomas Wilhelm; Starke, Ludger; Niendorf, Thoralf; Waiczies, Sonia

doi:10.1007/s10334-018-0722-8

Cited by 16 publications

(23 citation statements)

References 28 publications

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“…Here, thermoresponsive nanocarriers loaded with MR-sensitive fluorine ( 19 F) probes could provide ideal means to monitor release kinetics and bioavailability [ 45 ] of the MR visible cargo in vivo which would be a major leap forward to temperature-induced drug delivery in vivo. Similar to 1 H MR thermometry, fluorine resonance frequency ( 19 F) is also affected by temperature [ 46 ]. This feature can be exploited for temperature monitoring of fluorinated probes.…”

Section: Discussionmentioning

confidence: 99%

Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study

Winter

Navarro

et al. 2020

Cancers

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Thermal magnetic resonance (ThermalMR) accommodates radio frequency (RF)-induced temperature modulation, thermometry, anatomic and functional imaging, and (nano)molecular probing in an integrated RF applicator. This study examines the feasibility of ThermalMR for the controlled release of a model therapeutics from thermoresponsive nanogels using a 7.0-tesla whole-body MR scanner en route to local drug-delivery-based anticancer treatments. The capacity of ThermalMR is demonstrated in a model system involving the release of fluorescein-labeled bovine serum albumin (BSA-FITC, a model therapeutic) from nanometer-scale polymeric networks. These networks contain thermoresponsive polymers that bestow environmental responsiveness to physiologically relevant changes in temperature. The release profile obtained for the reference data derived from a water bath setup used for temperature stimulation is in accordance with the release kinetics deduced from the ThermalMR setup. In conclusion, ThermalMR adds a thermal intervention dimension to an MRI device and provides an ideal testbed for the study of the temperature-induced release of drugs, magnetic resonance (MR) probes, and other agents from thermoresponsive carriers. Integrating diagnostic imaging, temperature intervention, and temperature response control, ThermalMR is conceptually appealing for the study of the role of temperature in biology and disease and for the pursuit of personalized therapeutic drug delivery approaches for better patient care.

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Section: Discussionmentioning

confidence: 99%

Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study

Winter

Navarro

et al. 2020

Cancers

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“…Fluorine-19 ( 19 F) MR methods have found their application in a wide range of biomedical research areas including renal imaging [1][2][3][4][5][6][7][8]. The sensitivity constraints, low signal-to-noise ratio (SNR) and sparse signal distribution typical of fluorine-19 MRI necessitate a thorough data preparation.…”

Section: Introductionmentioning

confidence: 99%

Data Preparation Protocol for Low Signal-to-Noise Ratio Fluorine-19 MRI

Starke

Niendorf

Waiczies

2021

Methods in Molecular Biology

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Fluorine-19 MRI shows great promise for a wide range of applications including renal imaging, yet the typically low signal-to-noise ratios and sparse signal distribution necessitate a thorough data preparation.This chapter describes a general data preparation workflow for fluorine MRI experiments. The main processing steps are: (1) estimation of noise level, (2) correction of noise-induced bias and (3) background subtraction. The protocol is supplemented by an example script and toolbox available online.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This analysis protocol chapter is complemented by two separate chapters describing the basic concept and experimental procedure.

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“…In vivo thermometry and thermal dose management are essential for temperature‐triggered interventions or drug delivery, and are at the forefront of the awareness and attention of the corresponding research communities. Similar to proton, the fluorine resonance frequency is also affected by temperature and can be exploited for temperature monitoring of fluorinated probes …”

Section: Introductionmentioning

confidence: 99%

Wideband Self‐Grounded Bow‐Tie Antenna for Thermal MR

et al. 2020

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The objective of this study was the design, implementation, evaluation and application of a compact wideband self-grounded bow-tie (SGBT) radiofrequency (RF) antenna building block that supports anatomical proton ( 1 H) MRI, fluorine ( 19 F) MRI, MR thermometry and broadband thermal intervention integrated in a wholebody 7.0 T system. Design considerations and optimizations were conducted with numerical electromagnetic field (EMF) simulations to facilitate a broadband thermal intervention frequency of the RF antenna building block. RF transmission (B 1 + ) field efficiency and specific absorption rate (SAR) were obtained in a phantom, and the thigh of human voxel models (Ella, Duke) for 1 H and 19 F MRI at 7.0 T. B 1 + efficiency simulations were validated with actual flip-angle imaging measurements. The feasibility of thermal intervention was examined by temperature simulations (f = 300, 400 and 500 MHz) in a phantom. The RF heating intervention (P in = 100 W, t = 120 seconds) was validated experimentally using the proton resonance shift method and fiberoptic probes for temperature monitoring. The applicability of the SGBT RF antenna building block for in vivo 1 H and 19 F MRI was demonstrated for the thigh and forearm of a healthy volunteer. The SGBT RF antenna building block facilitated 19 F and 1 H MRI at 7.0 T as well as broadband thermal intervention (234-561 MHz). For the thigh of the human voxel models, a B 1 + efficiency ≥11.8 μT/√kW was achieved at a depth of 50 mm. Temperature simulations and heating experiments in a phantom demonstrated a temperature increase ΔT >7 K at a depth of 10 mm.The compact SGBT antenna building block provides technology for the design of integrated high-density RF applicators and for the study of the role of temperature in

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Toward 19F magnetic resonance thermometry: spin–lattice and spin–spin-relaxation times and temperature dependence of fluorinated drugs at 9.4 T

Cited by 16 publications

References 28 publications

Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study

Controlled Release of Therapeutics from Thermoresponsive Nanogels: A Thermal Magnetic Resonance Feasibility Study

Data Preparation Protocol for Low Signal-to-Noise Ratio Fluorine-19 MRI

Wideband Self‐Grounded Bow‐Tie Antenna for Thermal MR

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