Touch, sound and vision in human superior temporal sulcus

Beauchamp, Michael S.; Yasar, Nafi; Frye, Richard E.; Ro, Tony

doi:10.1016/j.neuroimage.2008.03.015

Cited by 174 publications

(160 citation statements)

References 65 publications

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“…Multisensory zones are frequently located on such borders between unisensory cortices (Wallace et al, 2004;Beauchamp et al, 2008). Interactions between auditory and somatosensory modalities in the perisylvian region have been suggested by imaging studies showing overlapping responses to sound and touch in this region (Foxe et al, 2002;Ozcan et al, 2005;Schurmann et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Neural Substrates of Sound–Touch Synesthesia after a Thalamic Lesion

Beauchamp¹,

Ro²

2008

J. Neurosci.

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Neural plasticity induced by stroke can mediate positive outcomes, such as recovery of function, but can also result in the formation of abnormal connections with negative consequences for perception and cognition. In three experiments using blood-oxygen level dependent (BOLD) functional magnetic resonance imaging, we examined the neural substrates of acquired auditory-tactile synesthesia, in which certain sounds can produce an intense somatosensory tingling sensation in a patient with a thalamic lesion. Compared with nine normal controls, the first experiment showed that the patient had a threefold greater BOLD response to sounds in the parietal operculum, the location of secondary somatosensory cortex. We hypothesized that this abnormal opercular activity might be the neural substrate of the patient's synesthesia. Supporting this hypothesis, the second experiment demonstrated that sounds that produced no somatosensation did not evoke a BOLD response in the operculum, while sounds that produced strong somatosensations evoked large BOLD responses. These abnormal responses may have resulted from plasticity induced by the loss of somatosensory inputs. Consistent with this idea, in the third experiment, BOLD responses to somatosensory stimulation were significantly weaker in the patient's operculum than in normal controls. These experiments demonstrate a double dissociation in the patient's secondary somatosensory cortex (increased responses to auditory stimulation and decreased responses to somatosensory stimulation), and suggest both that stroke-induced plasticity can result in abnormal connections between sensory modalities that are normally separate, and that synesthesia can be caused by inappropriate connections between nearby cortical territories.

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Section: Discussionmentioning

confidence: 99%

“…3A). The somatosensory stimuli were delivered using piezoelectric benders attached with elastic bandages (Beauchamp et al, , 2008. When activated, the benders (67 mm ϫ 32 mm) produced an intense vibrotactile percept similar to that of holding a vibrating pager or cell phone, without any accompanying auditory stimulation.…”

Section: Methodsmentioning

confidence: 99%

Neural Substrates of Sound–Touch Synesthesia after a Thalamic Lesion

Beauchamp¹,

Ro²

2008

J. Neurosci.

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“…The upper bank of the superior temporal sulcus (uSTS) is one of the regions in the primate brain frequently implicated in integrating sensory information across modalities (Jones and Powell, 1970;Calvert, 2001;Ghazanfar and Schroeder, 2006;Beauchamp et al, 2008). The uSTS contains an anatomically defined multisensory region, the so-called temporal polysensory area, that receives sensory-related inputs from visual, auditory, and somatosensory cortices (Seltzer and Pandya, 1989;Barnes and Pandya, 1992;Padberg et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Spatial Organization of Multisensory Responses in Temporal Association Cortex

Dahl¹,

Logothetis²,

Kayser³

2009

J. Neurosci.

103

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Neurons in sensory cortices are often topographically organized according to their response preferences. We here show that such an organization of response preferences also exists in multisensory association cortex. Using electrophysiological mappings, we probed the modality preference to auditory and visual stimuli of neurons in the superior temporal association cortex of nonhuman primates. We found that neurons preferring the same modality (auditory or visual) often co-occur in close spatial proximity or occur intermingled with bimodal neurons. Neurons preferring different modalities, in contrast, occur spatially separated. This organization at the scale of individual neurons leads to extended patches of same modality preference when analyzed at the scale of millimeters, revealing largerscale regions that preferentially respond to the same modality. In addition, we find that neurons exhibiting signs of multisensory interactions, such as superadditive or subadditive response summation, also occur in spatial clusters. Together, these results reveal a spatial organization of modality preferences in a higher association cortex and lend support to the notion that topographical organizations might serve as a general principle of integrating information within and across the sensory modalities.

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“…It suggests a short-term acquisition of a new motor pattern related to the typewriting task. Previous studies reported this region as a multisensory integration center 15 . despite the sensorimotor features of the task, in the training early phase the subjects possibly used secondary cues such as, the visual information from typewrite (e.g., letters on the paper) and the sound emitted by pressing of each key.…”

Section: Changes In Alpha Asymmetry (8-12 Hz)mentioning

confidence: 89%

Effects of a cognitive modulator in the theta and alpha asymmetry during a typewriting task: a sensorimotor integration perspective

Cunha

Machado

Miana

et al. 2009

Arq. Neuro-Psiquiatr.

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-This study aimed to elucidate cortical mechanisms and to identify the areas where occur such mechanisms due to interaction between bromazepam and motor learning. The sample was composed of 45 healthy subjects randomly distributed in 3 groups: placebo (n=15), bromazepam 3 mg (n=15) or bromazepam 6 mg (n=15). To perform the experimental task, subjects sat comfortably at a distance of approximately 20 cm from the typewriter. The typewriter keyboard was covered with a wooden box to avoid visual information about the hands' position. The typewriting task was performed concomitantly with EEG recording. ANOVA two-way results indicated a decreased asymmetry in sensorimotor areas in the experimental groups. Our interpretation is that moderate doses of bromazepam may improve performance on tasks with predictable elements to promote stability of psychomotor functions, but may also impair performance on tasks executed in unpredictable environments.KEy wOrds: bromazepam, motor learning, qEEG, asymmetry, sensorimotor integration.Efeitos de um modulador cognitivo na assimetria de teta e alfa durante uma tarefa de datilografia: uma perspectiva da integração sensório-motora Resumo -O objetivo do estudo foi elucidar mecanismos corticais e identificar as áreas onde estas ocorrem tais mecanismos devido à interação entre bromazepam e aprendizagem motora. A amostra compreendeu 45 sujeitos hígidos distribuídos randomicamente em 3 grupos: placebo (n=15), bromazepam 3 mg (n=15) ou bromazepam 6 mg (n=15). Para a realização da tarefa experimental, sujeitos sentaram-se confortavelmente a uma distância de aproximadamente 20 cm da máquina de escrever. O teclado da máquina foi coberto com uma caixa de madeira para evitar informações visuais sobre a posição das mãos. O registro do EEGq ocorreu simultaneamente à tarefa de datilografia. Os resultados da ANOVA two-way indicaram menor assimetria em áreas sensório-motoras nos grupos experimentais. Nossa interpretação é que doses moderadas de bromazepam podem melhorar o desempenho em tarefas previsíveis por promover estabilidade das funções psicomotoras, mas pode prejudicar o desempenho em tarefas realizadas em ambientes imprevisíveis.PAlAVrAs-ChAVE: bromazepam, aprendizagem motora, EEGq, assimetria, integração sensório-motora.

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Touch, sound and vision in human superior temporal sulcus

Cited by 174 publications

References 65 publications

Neural Substrates of Sound–Touch Synesthesia after a Thalamic Lesion

Neural Substrates of Sound–Touch Synesthesia after a Thalamic Lesion

Spatial Organization of Multisensory Responses in Temporal Association Cortex

Effects of a cognitive modulator in the theta and alpha asymmetry during a typewriting task: a sensorimotor integration perspective

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