Totally Drug-Resistant Tuberculosis in India

Immigrants and tuberculosis in Hong Kong

“…These higher risks among immigrants may have resulted at least in part from reactivation of latent TB infection 9-11 acquired during their previous residence in, and/or travel to, their places of birth with higher burdens of TB and/ or drug resistance. 1, [19][20][21][22] Apart from possible selection factors in migration, the progressive fall in TB prevalence in the Mainland over the recent decades 22 could also have contributed to a lower burden of latent TB infection, and hence SIR, among recent Mainland immigrants compared with those who immigrated longer ago. Taking into consideration the independent effects of birth outside Hong Kong on both treatment outcome and relapse (Table 5 and Fig), population mobility may have adversely affected treatment adherence, and thus impacted on treatment outcome and/or relapse with possible acquisition of drug resistance.…”

Crystal structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis

“…Totally drug-resistant TB was recently identified, indicating that even second-line drugs can be misused and become ineffective. [4][5][6][7][8] Combined, the emergence of drugresistant TB complicates treatment, poses a significant risk to global public health, and challenges our expectation for TB control and elimination.…”

Quality of tuberculosis care in India: A systematic review

“…This lack of awareness is surprising, and may not only explain the observed diagnostic delays shown in systematic reviews, 5 but may also partly explain the high levels of treatment failure and drug resistance reported in recent studies. 63,64 These data emphasise the need for greater investment in strategies that facilitate effective dissemination and implementation of the ISTC and STCI.…”