Total Tumor Uptake and Absorbed Dose of 177Lu-Lilotomab Satetraxetan in a First in Human Trial for Relapsed Non-Hodgkin Lymphoma - Are We Hitting the Target?
Abstract:Purpose: 177Lu-lilotomab satetraxetan, a novel CD37 directed radioimmunotherapy (RIT), has been investigated in a first-in-human phase 1/2a study for relapsed non-Hodgkin lymphoma (NHL). Absorbed dose for all tumor tissue in the body is a crucial parameter in RIT which has traditionally been challenging to calculate. The aim of this study was to investigate the correlations between baseline FDG PET/CT and posttreatment SPECT/CT parameters, absorbed dose-response relationships and clinical responses.Materials a… Show more
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