Total synthesis, structure elucidation and expanded bioactivity of icosalide A: effect of lipophilicity and ester to amide substitution on its bioactivity

Abstract

The first total synthesis of Icosalide A, an antibacterial depsipeptide unique in containing two lipophilic beta hydroxy acids has been achieved by following Fmoc solid-phase peptide synthesis in combination with...

Insights into the Potential Role of Gordonia alkanivorans Strains in Biotechnologies

“…It has shown activity against entomopathogenic bacteria [92,93]. There is also information of icosalides, which shows certain inhibitory activity against the active stage of Mycobacterium tuberculosis and some cancer cell lines [94]. Therefore, considering the fact that actinomycete genomes often contain «silent» genes [95], members of the genus Gordonia may have significant potential for producing various novel natural products.…”