Total synthesis of the proposed structure of metacridamide B

Concise total synthesis and structure revision of metacridamides A and B

“…During our synthetic efforts for the metacridamides, Ghosh, S. et al reported the total synthesis of the proposed structure of metacridamide B ( 1b ), in which the absolute configuration of the C-9 carbon was suggested to be revised as the S configuration. 2 Additionally, we carefully validated the X-ray structure of metacridamide A ( 1a ) (CCDC 840273†) at the beginning of our synthetic study of 1a , resulting in the absolute configuration of the C-9 carbon that was found to be S . Based on these considerations, the structure of metacridamide A ( 1a ) should be revised to 1a′ .…”