“…However, thus far, there have been few studies on the synthesis of these compounds using MNBA. 10 Recently, we achieved the total synthesis of (9R,14R,17R)-(−)-FE399 (1), 9,11 a novel bicyclic depsipeptide, in which both the formation of a dipeptide composed of two L-cystein residues and the creation of a macrolactam core of FE399 were shown to be effectively performed by the MNBA-mediated dehydration condensation reaction. Remarkably, this synthesis is the first application of MNBA-mediated macrolactamization for the total synthesis of natural products (Figure 1).…”