Total Synthesis of (±)-Simonsol C

Abstract

Total synthesis of simonsol C has been achieved, focusing on the postdearomatization transformations. Our methodology integrates an efficient combination of dearomatization and Zn/AcOH reduction to introduce an allyl group, followed by oxo-Michael addition, to construct the 6/5/6 benzofuran skeleton. It offers a novel method for synthesizing allyl-containing quaternary carbon atoms in a straightforward manner.

Total synthesis, biological evaluation and biosynthetic re-evaluation of Illicium-derived neolignans

“…12 This was followed by a second total synthesis which was very recently disclosed by Qin and co-workers. 13 Banwell's observation, coupled with the fact that several structurally related neolignans have been shown to exhibit neuroprotective effects, 14–19 stimulated our interest in this family, and analogs thereof, as a possible source of new neuroprotective compounds.…”