Total Synthesis of Silyl‐Protected Early Intermediates of Polyketide Biosynthesis

Krohn, Karsten; Vidal, Anne; Tran-Thien, Hoan Trang; Flörke, Ülrich; Bechthold, Andreas; Dujardin, Gilles; Green, Ivan R.

doi:10.1002/ejoc.201000067

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Biomimetic Access To Tetraphenoid Derivatives1

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“…For example, they used dibromonaphthoquinone 130 as the starting material to synthesize tetrangomycin (131) by a combination of biomimetic and conventional chemistries (Scheme 13.40) [77]. The same group was able to perform the syntheses of the closely related angucyclinone, aquayamycin, and WP 3688-2 using a SmI 2 -mediated cyclization of ketides [78,79].…”

Section: Biomimetic Access To Tetraphenoid Derivativesmentioning

confidence: 99%

Polyketide Assembly Mimics and Biomimetic Access to Aromatic Rings

Genta‐Jouve

Antoniotti

Thomas

2011

Biomimetic Organic Synthesis

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Section: Biomimetic Access To Tetraphenoid Derivativesmentioning

confidence: 99%

Polyketide Assembly Mimics and Biomimetic Access to Aromatic Rings

Genta‐Jouve

Antoniotti

Thomas

2011

Biomimetic Organic Synthesis

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New Isocoumarins from a Cold‐Adapted Fungal Strain Mucor sp. and Their Developmental Toxicity to Zebrafish Embryos

Feng

Chen

Zhao

et al. 2014

Chemistry & Biodiversity

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Three new isocoumarin derivatives, mucorisocoumarins A-C (1-3, resp.), together with seven known compounds, 4-10, were isolated from the cold-adapted fungal strain Mucor sp. (No. XJ07027-5). The structures of the new compounds were identified by detailed IR, MS, and 1D- and 2D-NMR analyses. It was noteworthy that compounds 1, 2, 4, and 5 were successfully resolved by chiral HPLC, indicating that 1-7 should exist as enantiomers. In an embryonic developmental toxicity assay using a zebrafish model, compound 3 produced developmental abnormalities in the zebrafish embryos. This is the first report of isocoumarins with developmental toxicity to zebrafish embryos.

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