Abstract:We have accomplished the total synthesis of sculponin U, a polycyclic C‐20‐oxygenated kaurane diterpenoid featuring a 7,20‐lactone‐hemiketal bridge, through a radical cascade cyclization triggered by photoinduced electron transfer (PET) of a silyl enolate to form the cyclohexanone‐fused bicyclo[3.2.1]octane skeleton. Other key points in our synthetic strategy encompass a Diels–Alder reaction to construct the middle six‐membered ring of sculponin U, and an intramolecular radical cyclization induced by iron‐cata… Show more
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