Total Synthesis of Phorboxazole A

The Total Syntheses of Phorboxazoles—New Classics in Natural Product Synthesis

“…[4] They relied on a highly convergent strategy for the assembly of the phorboxazole skeleton, employing three fragments of comparable complexity (C3-C17, C18-C30, and C31-C46) (Figure 1).…”

Die Totalsynthesen der Phorboxazole – neue Klassiker in der Naturstoffsynthese

“…[4] Forsyth wendete dabei eine hochkonvergente Strategie zum Aufbau des Phorboxazol-Gerüstes an, die auf drei Fragmenten vergleichbarer Komplexität (C3-C17, C18-C30 und C31-C46) beruhte (Abbildung 1).…”

Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks

“…In recent years, a wide range of chemically and biologically important oxazoles with 2,4-disubstitution pattern have been studied, specifically protein kinase inhibitor mubritinib (5), [8] and antimicrobal phenoxan (6). cytostatic anti-mitotic phorboxazoles, [12,13] antibiotic rhizoxins, [14,15] cytotoxic enigmazole A, [16] steptogramin antibiotic virginiamycins, [17][18][19][20] and acyclic serine/threonine protein phosphatase inhibitors calyculins. cytostatic anti-mitotic phorboxazoles, [12,13] antibiotic rhizoxins, [14,15] cytotoxic enigmazole A, [16] steptogramin antibiotic virginiamycins, [17][18][19][20] and acyclic serine/threonine protein phosphatase inhibitors calyculins.…”