Total Synthesis of Natural Products using Gold Catalysis

Abstract

Gold catalysis is an extremely enthusiastic field of investigation in the catalysis area. The development of alternative, highly inventive, precompetitive techniques based on gold catalysis has paved the way for executing a broad spectrum of chemical transformations from uncomplicated starting materials. The total synthesis of natural products is a complex and more complicated task. An amalgamation of natural product synthesis through goldcatalysis has been a thought-provoking job. The protocol has solved several problems related to the synthesis of numerous complicated natural products. Thus, this review has outlined some of the most notable benchmarks from the last seven years (2015-2021) on gold catalysis and their application in the total synthesis of numerous natural products. The strategy acquired by the authors to accomplish the total synthesis will be elaborately discussed by emphasizing the role of the gold-catalyzed reactions.

Transition-Metal-Catalyzed Transformations for the Synthesis of Marine Drugs

“…Gold exists in two stable oxidation states, +1 and +3, each exhibiting distinct behavior when interacting with organic molecules. While significant advancements are being made in the field of gold(III) catalysis [87], gold(I) remains predominant, being the most commonly employed species in total synthesis [88,89]. Thus, the evolution of gold catalysis has enabled the development of a broad spectrum of intramolecular and intermolecular transformations, including bis-spiroketalization, hydroalkoxylation, hydrocarboxylation, hydroamination, hydroarylation, oxidation and glycosylation reactions of particularly alkynes, as well as intriguing cycloisomerizations and rearrangements of enynes [83].…”

Homogeneous Gold Catalysis for Regioselective Carbocyclization of Alkynyl Precursors

“…[25][26][27][28][29][30][31][32][33][34][35][36] Moreover, bonding model of gold complexes [37][38][39] and organogold intermediates [40][41][42][43] have recently gained momentum in understanding the structure guided reactivity patterns. These revelations have indeed spurred the interests of organic/organometallic community to utilize gold catalysis as a synthetic tool in application-oriented areas like natural products [44][45][46][47][48][49][50] and πfunctional materials. [51] Among the different substrate classes, the chemistry of alkynes under gold catalysis is one of the earliest and wellestablished topics.…”