Abstract:Herein, we report the total synthesis of nagelamide W
(1), a pyrrole imidazole alkaloid of the nagelamide family
isolated
in 2013. The key approach in this work involves the construction of
the 2-aminoimidazoline core of nagelamide W from alkene 6 through
a cyanamide bromide intermediate. The synthesis of nagelamide W was
accomplished with an overall yield of 6.0%.
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