Total Synthesis of Leucosceptroids A and B

Guo, Sheng; Liu, Jie; Ma, Dawei

doi:10.1002/anie.201410134

Cited by 42 publications

(25 citation statements)

References 33 publications

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“…39 This carbomagnesiation procedure was applied by the Ma group for an alkyne methylation to obtain intermediate 111 for the total synthesis of leucosceptroids A and B (Scheme 12, f). 40…”

Section: Short Review Syn Thesismentioning

confidence: 99%

Tris(acetylacetonato) Iron(III): Recent Developments and Synthetic Applications

2018

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Tris(acetylacetonato) iron(III) [Fe(acac)3] is an indispensable reagent in synthetic chemistry. Its applications range from hydrogen atom transfer to cross-coupling reactions and to use as a Lewis acid. Consequently, the exceptional utility of Fe(acac)3 has been demonstrated in several total syntheses. This short review summarizes the applications of Fe(acac)3 in methodology and catalysis and highlights its use for the synthesis of medicinally relevant structures and in natural product syntheses.1 Introduction2 Hydrogen Atom Transfer (HAT)3 Oxidations and Radical Transformations4 Synthesis and Use of Alkynes and Allenes5 Cross-Couplings and Cycloisomerizations6 Borylations7 Miscellaneous Reactions8 Conclusions

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“…39 This carbomagnesiation procedure was applied by the Ma group for an alkyne methylation to obtain intermediate 111 for the total synthesis of leucosceptroids A and B (Scheme 12, f). 40…”

Section: Short Review Syn Thesismentioning

confidence: 99%

Tris(acetylacetonato) Iron(III): Recent Developments and Synthetic Applications

2018

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“…Ma et al described the total syntheses of leucosceptroids A ( 139 ) and B ( 138 ) by applying a SmI 2 -mediated intramolecular ketyl-olefin radical cyclization ( Scheme 21 ) [ 82 ]. These two sesterterpenoids were separated from glandilar trichomes of Leucosceptrum canum [ 83 ].…”

Section: Radical Cyclizationsmentioning

confidence: 99%

Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis

Kim

Han

et al. 2017

Molecules

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Asymmetric synthesis of naturally occurring diverse ring systems is an ongoing and challenging research topic. A large variety of remarkable reactions utilizing chiral substrates, auxiliaries, reagents, and catalysts have been intensively investigated. This review specifically describes recent advances in successful asymmetric cyclization reactions to generate cyclic architectures of various natural products in a substrate-controlled manner.

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“…N-(phenylselenyl)phtalimide was used for the synthesis of the 11-epi-mandelalide A, by the group of Fürstner, 55 while phenylselenylchloride was used by the group of Ma for the synthesis of Leucosceptroids A M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT and B. 56 One recent example of a synthesis using mercuroetherification was also achieved by Mohapatra and co-workers, using mercury (II) acetate. 57 …”

Section: Scheme 17 : Unexpected Cyclization Toward the Synthesis Of Lmentioning

confidence: 99%

Recent advances in the synthesis of tetrahydrofurans and applications in total synthesis

et al. 2016

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Mousseron. His research interests include the total synthesis of oxygenated cyclic and non cyclic metabolites of polyunsaturated fatty acids, mainly leukotrienes, iso-, phyto-and neuroprostanes, as well as dihydroxylated PUFAs and more recently lipophenols and the understanding of the role of such bioactive lipids and lipophenols by developing collaborations with chemists, biochemists, biologists and clinicians across the world. Jean-Marie Galano studied chemistry at Paul Cézanne Université Marseille and obtained his PhD under the supervision of Honoré Monti in 2001. He then moved to the University of Oxford to pursue a postdoctoral fellowship with David H. Hodgson on the development of new methods for the total synthesis of natural products. In October 2005 he joined the CNRS as a Chargé de Recherche at Université of Montpellier. His research focuses on the total synthesis and discovery of new lipid metabolites, and to discover their potential implications in human health. AbstractMany natural products contain tetrahydrofuran (THF) moieties. Those molecules, often biologically active, may be structurally diverse, e.g. cis or trans THF, mono-, di-, tri-or tetrasubstituted on the furan ring. Thus, the construction of THF is of great interest for the community of organic chemists; especially in developing new methodologies, and applying them in the total synthesis of natural products. The aim of this review is to report recent advances in the field of THF synthesis, as well as the application of these methods to the synthesis of bioactive compounds.

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Total Synthesis of Leucosceptroids A and B

Cited by 42 publications

References 33 publications

Tris(acetylacetonato) Iron(III): Recent Developments and Synthetic Applications

Tris(acetylacetonato) Iron(III): Recent Developments and Synthetic Applications

Recent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis

Recent advances in the synthesis of tetrahydrofurans and applications in total synthesis

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