2021
DOI: 10.33774/chemrxiv-2021-0swk6
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Total Synthesis of Himastatin

Abstract: The synthesis and study of antibiotic natural products with unique structures and mechanisms of action represents a proven strategy to combat the public health crisis posed by antibiotic-resistant bacteria. The natural product himastatin is an antibiotic with an unusual homodimeric structure that presents a significant synthetic challenge. We report the concise total synthesis of himastatin by a newly developed final-stage dimerization strategy that was inspired by a detailed consideration of its biogenesis. C… Show more

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