“…After the formation of the maximum amount of the desired compound as monitored by TLC analysis, the mixture was then concentrated under reduced pressure and the crude product was purified through flash column chromatography (EtOAc : hexane (m, 2H), 6.81-6.72 (m, 1H), 6.33 (dd, J = 5.6, 1.9 Hz, 1H), 3.87 (s, 3H). 13 The compound was synthesized by following a general procedure for bimetallic cascade cyclization as described earlier from 1-bromo-2-ethynylbenzene and Z-3-bromoacrylic acid to afford 204 mg (80%) of 3i as a liquid. 1 H NMR (500 MHz, CDCl 3 ) δ: 8.17 Compound 3k was prepared from 5-methylhex-1-yn-3-ol following the general procedure of bimetallic cascade cyclization in 80% yield.…”