Total Synthesis of Cytosporone B

Huang, He; Zhang, Lei; Zhang, Xiaodong; Ji, Xun; Ding, Xiao; Shen, Xu; Jiang, Hualiang; Hong, Liu

doi:10.1002/cjoc.201090163

Cited by 22 publications

(14 citation statements)

References 21 publications

(24 reference statements)

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“…2 presents the FT-IR spectra of precursor (sample a) and nano-CuO/ZnO products obtained at various calcining temperatures (samples b-f). Compared with spectrum a, the characteristic absorption bands between 700 cm −1 and 1100 cm −1 disappear in spectra b-f, and the two strong characteristic absorption bands at 1384 cm −1 and 1504 cm −1 almost disappear too, corresponding to the decomposition of the carbonate and hydroxy of the procursor [19]; a wide band at about 450 cm −1 , however, appears, which is attributed to the characteristic absorption band of Zn-O [19]. According to Fig.…”

Section: Photocatalytic Activitymentioning

confidence: 92%

Fabrication and photocatalysis of CuO/ZnO nano-composites via a new method

Liu

Jing

Deng

et al. 2008

Materials Science and Engineering: B

135

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Section: Photocatalytic Activitymentioning

confidence: 92%

Fabrication and photocatalysis of CuO/ZnO nano-composites via a new method

Liu

Jing

Deng

et al. 2008

Materials Science and Engineering: B

135

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“…This result suggests that Csn-B interferes with the HilA expression pathway. A route for Csn-B total synthesis was published in 2010 [61], but since then, very little has been done to further this compound as a T3SS inhibitor.…”

Section: Cytosporone Bmentioning

confidence: 99%

Natural Product Type III Secretion System Inhibitors

Pendergrass

May

2019

Antibiotics

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Many known inhibitors of the bacterial type III secretion system (T3SS), a virulence factor used by pathogenic bacteria to infect host cells, are natural products. These compounds, produced by bacteria, fungi, and plants, may have developed as prophylactic treatments for potential attack by bacterial pathogens or as an attempt by symbiotic organisms to protect their hosts. Regardless, better understanding of the structures and mechanisms of action of these compounds may open opportunities for drug development against diseases caused by pathogens utilizing the T3SS. This review will cover selected known natural products of the T3SS and detail what is known of their origin and mechanism of action. These inhibitors highlight nature’s ability to modulate interactions between organisms at a cellular level.

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“…Characterization data of cytosporones A-C were in complete agreement with the literature data reported by Brady et al 3 The total syntheses of cytosporones A and C have not been reported in the literature. As for cytosporone B, the synthesis was recently reported by Huang et al 16 in a 44% global yield. The authors have prepared the intermediate 12 (Scheme 3) by esterification of the corresponding acid 6 followed by Friedel-Crafts reaction to connect the acyl group to the aromatic ring.…”

Section: Synthesismentioning

confidence: 99%

Total synthesis and allelopathic activity of cytosporones A-C

Zamberlam¹,

Meza²,

Leite³

et al. 2012

J. Braz. Chem. Soc.

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A busca por herbicidas eficientes e ambientalmente corretos tem sido foco de numerosos estudos sobre a síntese de compostos isolados de fontes naturais. Citosporonas, as quais são lipídeos fenólicos isolados de fungos, apresentam notáveis propriedades biológicas. Este artigo relata a preparação das citosporonas A, B e C, através de uma rota sintética curta e com excelentes rendimentos. Os compostos sintetizados foram avaliados quanto às suas atividades alelopáticas em sementes de alface (Lactuca sativa L). Citosporona A e seu precursor metilado mostraram notável atividade alelopática, inibindo a germinação de sementes e crescimento das plântulas.The search for efficient, environmentally friendly herbicides has been the focus of numerous studies on the organic synthesis of compounds isolated from natural sources. Cytosporones, which are phenolic lipids isolated from fungi, exhibit noteworthy biological properties. This paper reports the preparation of cytosporones A-C from the same starting material through a short synthetic route, with good yields. All compounds were tested for allelopathic activity on lettuce (Lactuca sativa L) seeds. Cytosporone A and its methylated precursor showed remarkable allelopathic activity, inhibiting seed germination and plantule growth.

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Total Synthesis of Cytosporone B

Cited by 22 publications

References 21 publications

Fabrication and photocatalysis of CuO/ZnO nano-composites via a new method

Fabrication and photocatalysis of CuO/ZnO nano-composites via a new method

Natural Product Type III Secretion System Inhibitors

Total synthesis and allelopathic activity of cytosporones A-C

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