Total Synthesis of Cyanobactin Natural Product Balgacyclamide B
Arnaldo X. Torres‐Hernandez,
Prathibha Desman,
Thi Nguyen
et al.
Abstract:Balgacyclamide A−C are a family of cyanobactin natural products isolated from freshwater cyanobacteria Microcystis aeruginosa. These macrocyclic peptides are characterized by their oxazoline‐thiazole core, their 7 or 8 stereocenters, and their antiparasitic activities. Balgacyclamide B is known for its activity towards Plasmodium falciparum chloroquine‐resistant strain K1, Trypanosoma brucei rhodesiense, and Leishmania donovani. In this report, the first total synthesis of Balgacyclamide B is described in a 17… Show more
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