Total Synthesis of Clavosolide A via Asymmetric Alcohol‐Mediated Carbonyl Allylation: Beyond Protecting Groups or Chiral Auxiliaries in Polyketide Construction

Abstract

The 20-membered marine macrodiolide clavosolide Aisprepared in 7steps (LLS) in the absence of protecting groups or chiral auxiliaries via enantioselective alcoholmediated carbonyl addition. In 9p rior total syntheses,1 1-34 steps (LLS) were required.