Total Synthesis and Antibacterial Activity of Marine Tris-indole Alkaloid Tulongicin A
Shuji Tsuruda,
Takumi Sato,
Hiroshi Aoyama
et al.
Abstract:Bis-indole alkaloids from marine sponges are an intriguing class of natural products with a variety of activities. However, only a preliminary biological study of tulongicin A (5), a related previously isolated marine tris-indole alkaloid, has been conducted. In this study, we accomplished the first asymmetric total synthesis of 5 via the construction of an imidazoline-linked bisindolylmethane skeleton using a Friedel−Crafts-type reaction. Our synthesis enabled a detailed study of the antibacterial profile of … Show more
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