Total syntheses of hyperaspidinols A and B enabled by a bioinspired diastereoselective cascade sequence

Digital Regeneration and Database Construction of Hunan Embroidery Needlework under the Perspective of Artificial Intelligence

“…However, traditional Hunan embroidery has a small consumer market space, and there are many problems, such as single structure, monotonous form, and insufficient creativity in many aspects of product types, quality, function, decoration, subject matter, packaging, and preservation, which are still far from meeting the growing cultural needs of people []- [21]. The sharp decline in cultural status has made the development of Hunan embroidery face great challenges [22]. Under the wave of rapid development of cultural tourism and supply-side to structural reform, expanding the Hunan embroidery market into the Hunan tourism industry market is bound to bring a new dawn to the Hunan embroidery industry []- [24].…”

Bioinspired syntheses of cryptoflavanones C and D, oboflavanones A and B, and cryptoyunnanones G and H enabled by an acid-triggered cascade sequence

“…Inspired by their proposed biogenesis reported by the Zhang group 14 and encouraged by the previous research on the successful total syntheses of myrtucommuacetalone, sanctis, tomentosones, diinsininone, flavonoids, peniciketal A, 15 b and hyperaspidinols 16 via similar formal intermolecular [3 + 3]-type cycloaddition cascade processes, we envisioned that (−)-oboflavanones A and B ( 1 and 2 ), cryptoflavanones C and D ( 3 and 4 ), and (−)-cryptoyunnanones G and H ( 5 and 6 ) could all evolve from (2 S /2 R )-5,7-dihydroxyflavanone ( 15 ) by hybridization with the corresponding hydroxyl vinyl ketone via an olefin isomerization/hemiacetalization/dehydration/Friedel–Crafts alkylative formal [3 + 3]-type cycloaddition cascade sequence. Retro-synthetically, cryptoflavanones C and D ( 3 and 4 ) and (−)-cryptoyunnanones G and H ( 5 and 6 ) could be accessed in one pot via regio-divergent Friedel–Crafts alkylative formal [3 + 3]-type cycloaddition between 15 and oxonium intermediate 14 generated in situ from the corresponding hydroxyl vinyl ketone 13 through an E / Z double bond isomerization/hemiacetalization/dehydration sequence (Scheme 1).…”