Total specific airway resistance vs spirometry in asthma evaluation in children in a large real-life population

Jerzyńska, Joanna; Janas, Anna; Galica, Katarzyna; Stelmach, Włodzimierz; Woicka-Kolejwa, Katarzyna; Stelmach, Iwona

doi:10.1016/j.anai.2015.07.002

Cited by 11 publications

(11 citation statements)

References 22 publications

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“…A standard cut-off of 12% of predicted value for reversibility in FEV 1 was employed [ 1 ]. Improvement in the pre-bronchodilator sRtot and Rint after administration of salbutamol ≥ 25% and ≥ 35% was assessed [ 2 , 6 , 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…Detailed information on the methods employed is available in our previous papers [ 6 , 10 , 11 ] and in other authors’ publications [ 1 , 2 , 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

“…However, other methods assessing airway function that do not require complex respiratory manoeuvers are necessary. The most common methods for measurement of airway resistance that require less cooperation and less physical effort from the patient are plethysmography and the interrupter technique [ 3 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Bobrowska-Korzeniowska¹,

Brzozowska²,

Jerzyńska³

et al. 2020

pdia

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Section: Methodsmentioning

confidence: 99%

“…Detailed information on the methods employed is available in our previous papers [ 6 , 10 , 11 ] and in other authors’ publications [ 1 , 2 , 12 , 13 ].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Bobrowska-Korzeniowska¹,

Brzozowska²,

Jerzyńska³

et al. 2020

pdia

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“…Total specific airway resistance (sRtot) measured by body plethysmography deserves increasing interest as it is non‐invasive, easy to perform and requires only minimal patient cooperation. A recent study has shown its high sensitivity and sensibility in identifying children with reversible obstruction .…”

Section: Diagnostic Tools and Monitoringmentioning

confidence: 99%

Respiratory allergies in childhood: Recent advances and future challenges

Caminati

Đurić-Filipović

Arasi

et al. 2015

Pediatric Allergy Immunology

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The burden of allergic airway diseases still represents a major health problem in childhood. Despite many different options are currently available for the diagnostic work-up and management, the overall disease control in terms of impact on quality of life, morbidity and mortality, is not yet satisfactory. The extreme variability of individual risk factors and severity determinants may account for it. On the other side, the knowledge of the multifaceted allergy background could pave the way to primary prevention, early intervention and disease course modification. In fact, most of current research is focusing on the identification of biological and clinical predictive markers of allergy and asthma onset. This review aims at summarizing the latest achievements concerning the complex inter-relation between genetic predisposition and environmental factors, and their impact on prevention strategies and early identification of at risk subjects. An update on the diagnostic and monitoring tools as well as an insight into the newest treatments options is also provided.

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“…Another advantage compared to spirometry is its independence of the cooperation of participants. However, only a few studies investigated the role of body plethysmography in asthmatic children [15][16][17][18][19] and to the best of our knowledge, there are no studies available investigating the relationship between asthma control and the assessment of spirometry, body plethysmography, and FeNO.…”

Section: Introductionmentioning

confidence: 99%

Asthma control in children: Body plethysmography in addition to spirometry

Korten

Zacharasiewicz

Bittkowski³

et al. 2019

Pediatric Pulmonology

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Background There is a lack of agreement among measures of asthma control in children. In Central Europe, body plethysmography is additionally used for asthma monitoring. However, its value is still unclear. Objectives We investigated the possible additional value of body plethysmographic measures (specific resistance, residual volume‐total lung capacity ratio [RV/TLC]) compared with spirometric measures forced expiratory volume in 1 second (FEV 1), forced vital capacity (FVC), FEV 1/FVC, forced expiratory flow at 25% to 75% of forced vital capacity (FEF 25‐75), and fraction of exhaled nitric oxide (FeNO) for assessment of asthma control. Methods One hundred and forty‐five asthmatic children aged 5 to 17 were included. All children performed measurements of FeNO, spirometry, and body plethymography. Asthma control was assessed by the asthma control test (c‐ACT/ACT) and a doctor's assessment of asthma control. Results Investigating single lung function parameters, FEV1, FEV 1/FVC, FEF 25‐75 and RV/TLC differed between controlled and partly controlled asthma. However, we found no differences between controlled and uncontrolled asthma with regard to single lung function parameters or for any parameter if investigated in a multivariable approach. This was also true if we combined obtained parameters from spirometry (comparing pathologic vs normal spirometry). Investigating the combination of body plethysmography and doctor's assessment of asthma control a significant association was found ( P = 0.02). Furthermore, combined spirometry and body plethysmography showed a significant association with both doctor's assessed asthma control ( P = 0.009) and the c‐ACT/ACT ( P = 0.04). The addition of FeNO did not improve the results. Conclusions The combination of body plethysmography and spirometry shows best agreement with asthma control in children compared with spirometry or body plethysmography alone. Further studies are needed to find out whether additional measurements of body plethysmography improve the outcome of children in asthma monitoring.

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Total specific airway resistance vs spirometry in asthma evaluation in children in a large real-life population

Cited by 11 publications

References 22 publications

Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Usefulness of sRtot and Rint in bronchodilator testing in the diagnosis of asthma in children

Respiratory allergies in childhood: Recent advances and future challenges

Asthma control in children: Body plethysmography in addition to spirometry

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