Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

Staffe, Alexander Torp; Bech, Mathias Winther; Clemmensen, Sara Louise Kjær; Nielsen, H; Larsen, Dennis Boye; Petersen, Kristian Kjær

doi:10.1371/journal.pone.0225849

Cited by 88 publications

(97 citation statements)

References 67 publications

(92 reference statements)

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“…A widely accepted view in the scientific community is that sleep deprivation decreases pain tolerance and increases the transmission of pain in multiple chronic pain conditions [ 160 , 161 , 162 , 163 , 164 , 165 ]. There is a conflict between reports on the sensory perception of pain [ 166 , 167 ], which was negatively affected in our study ( Figure 3 B), and few studies indicated that only total sleep deprivation raises the intensity of pain rather than REM sleep deprivation [ 168 , 169 ]. Nonetheless, selective REM sleep deprivation is correlated with enhanced placebo analgesia effects [ 170 ].…”

Section: Discussioncontrasting

confidence: 87%

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

2020

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Sleep is essential for the survival of most living beings. Numerous researchers have identified a series of genes that are thought to regulate “sleep-state” or the “deprived state”. As sleep has a significant effect on physiology, we believe that lack of total sleep, or particularly rapid eye movement (REM) sleep, for a prolonged period would have a profound impact on various body tissues. Therefore, using the microarray method, we sought to determine which genes and processes are affected in the brain and liver of rats following nine days of REM sleep deprivation. Our findings showed that REM sleep deprivation affected a total of 652 genes in the brain and 426 genes in the liver. Only 23 genes were affected commonly, 10 oppositely, and 13 similarly across brain and liver tissue. Our results suggest that nine-day REM sleep deprivation differentially affects genes and processes in the brain and liver of rats.

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Section: Discussioncontrasting

confidence: 87%

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

2020

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“…A widely accepted view in the scientific community is that sleep deprivation decreases pain tolerance and increases the transmission of pain in multiple chronic pain conditions [158–163]. There is a conflict between reports on the sensory perception of pain [164,165] which was negatively affected in our study ( Fig. 3B ) and few studies indicated only total sleep deprivation raises the intensity of pain rather than REM sleep deprivation [166,167].…”

Section: Discussioncontrasting

confidence: 60%

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivation

Pandey

Oliver

Kar

2019

Preprint

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Short title:REM sleep deprivation differentially affects the genes of liver and brain in rats. Highlights of the study: Microarray analysis compared the expression pattern of genes related to many biological, molecular and physiological processes in brain and liver. Analysis revealed about the basic genetic tool-kit involved with REM sleep deprivation and its loss in brain and liver. Many of the genes involved in critical physiological processes like apoptosis and circadian rhythms are found differentially expresses in brain and liver. AbstractFundamental questions about sleep and its universal existence remain elusive. The common presence of sleep across phyla suggests that it must serve some indispensable cellular and/or molecular function needed for survival. Microarray studies, performed in several model systems, have identified classes of genes that are believed to regulate "sleep-state" or viceversa. This has led to the following concepts: first, a function of sleep is to maintain synaptic homeostasis; second, sleep is a stage of macromolecule biosynthesis which is needed during the waking period; third, extending wakefulness leads to the downregulation of several important metabolic pathways which needs to be balanced for extended survival; and, fourth, extending wakefulness leads to endoplasmic reticulum stress. In human sleep studies, microarrays are being pragmatic to the identification of biomarkers for sleepiness and for the common sleep disorders. This study tries to find out the correlative processes which happen across different tissue system in the maintenance of sleep. We compared the gene expression profile in brain and liver due to REM sleep deprivation. Our result suggests that sleep deprivation affects a different set of genes in the brain and liver.

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“…The present findings should be carefully interpreted in terms of the methodological limitation. Despite the theoretical backgrounds of unidirectional effect of disturbed sleep causing pain, 48,50,51 our cross‐sectional design prevents the causal relationships between sleep and pain. The conceptual hypothesis of mediation analysis in this study is that sleep may predict jaw functional limitation via pain.…”

Section: Discussionmentioning

confidence: 99%

Disturbed sleep may be a core risk factor for jaw functional limitation in patients with painful temporomandibular disorders

Kim

2021

J of Oral Rehabilitation

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Background Pain related to temporomandibular disorder (TMD) usually affects jaw function. In patients with TMD, little is known about the biopsychosocial relevance to jaw functional limitations. Objective This study explored the impact of biopsychosocial risk factors on jaw functional limitation in patients with painful TMD. Methods A comprehensive set of patient‐reported outcomes (PROs), consisting of pain severity (Brief Pain Inventory), psychological stress (Symptom Checklist‐90‐Revised), catastrophising thought (Pain Catastrophizing Scale), kinesiophobia (Tampa Scale for Kinesiophobia‐TMD), sleep quality (Pittsburgh Sleep Quality Index) and jaw functional limitation (Jaw Functional Limitation Scale‐20), were administered, and clinical examinations were performed in patients with TMD. Results This study included the data obtained from 131 patients with painful TMD. In the logistic regression analysis, biomedical factors (age, sex, pain duration and TMD phenotype) were not associated with jaw functional limitation. Correlations were higher in the order of sleep quality (ρ = 0.946), pain severity (ρ = 0.582), pain catastrophising (ρ = 0.535), kinesiophobia (ρ = 0.486) and emotional distress (ρ = 0.268). Multiple regression analysis demonstrated three predictors, including pain severity (p = .001), kinesiophobia (p = .023) and sleep quality (p < .001) for jaw functional limitation. In the mediation analysis, the indirect effect of pain severity on the association between sleep and limitation was significant (p < .0001). Conclusion Jaw functional limitation is associated with biopsychosocial factors. In particular, sleep may be a core risk factor for functional limitation in patients with painful TMD.

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Total sleep deprivation increases pain sensitivity, impairs conditioned pain modulation and facilitates temporal summation of pain in healthy participants

Cited by 88 publications

References 67 publications

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

Differential Gene Expression in Brain and Liver Tissue of Wistar Rats after Rapid Eye Movement Sleep Deprivation

Differential gene expression in brain and liver tissue of Wistar rats after rapid eye movement sleep deprivation

Disturbed sleep may be a core risk factor for jaw functional limitation in patients with painful temporomandibular disorders

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