Total sleep deprivation and thyroid function in depression

Kaschka, Wolfgang P.; Flügel, Dominique; Negele-Anetsberger, J.; Schlecht, Annette; Marienhagen, Jörg; Bratenstein, Peter

doi:10.1016/0165-1781(89)90038-3

Cited by 20 publications

(5 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…54 The elevated basal serum thyrotropin level in our SD responders increased in parallel with that of nonresponders and controls during SD but was higher throughout the sampling period; mean nocturnal serum thyrotropin level was above the upper normal limit in responders, but in none of the nonresponders or controls. The correlation of increased serum thyrotropin level with clinical response was robust in our patients, consistent with some 25,26 but not all 24,27 studies. The changes were limited to the HPT in our patients, since the circulating concentrations of cortisol, which also has a circadian secretory pattern, were normal and similar among the 3 groups.…”

Section: Two-year Follow-up Evaluationsupporting

confidence: 91%

“…Protirelin causes acute changes in sleep electroencephalograms in normal volunteers. 21,22 Thyrotropin secretion normally demonstrates a circadian rhythm, peaking during early sleep, 23 but nocturnal serum thyrotropin level continues to rise during SD, [24][25][26][27] associated with clinical improvement in some 25,26 but not all 24,27 studies. However, most investigators measured serum thyrotropin level infrequently or only compared hormone levels before and after SD.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Serum Thyrotropin Concentrations and Bioactivity During Sleep Deprivation in Depression

Orth¹,

Shelton²,

Nicholson³

et al. 2001

Arch Gen Psychiatry

View full text Add to dashboard Cite

show abstract

Section: Two-year Follow-up Evaluationsupporting

confidence: 91%

mentioning

confidence: 99%

Serum Thyrotropin Concentrations and Bioactivity During Sleep Deprivation in Depression

Orth¹,

Shelton²,

Nicholson³

et al. 2001

Arch Gen Psychiatry

View full text Add to dashboard Cite

show abstract

“…25 Several lines of evidence suggest that SD induces a variety of changes in neurobiological variables. Neuroendocrinological examination results indicate increased activity of the hypothalamic-pituitary-thyroid axis [26][27][28][29][30] with SD. Baseline nonsuppression of cortisol release after dexamethasone administration normalized to a suppressor status in SD responders.…”

Section: Discussionmentioning

confidence: 99%

Effects of Tryptophan Depletion in Drug-Free Depressed Patients Who Responded to Total Sleep Deprivation

Neumeister¹,

Praschak-Rieder²,

Heßelmann³

et al. 1998

Arch Gen Psychiatry

View full text Add to dashboard Cite

show abstract

“…The circadian variation of TSH secretion, showing low levels during the day and an increase after sleep onset with a maximum at midnight and subsequent returning to basal values until the morning [Souêtre et al, 1986;Wilson et al 1992], provides a further (indirect) argument that the HPT axis activity -and thus TRH -is involved in the regulation of sleep and nocturnal hormone secretion. Additional support for this hypothesis arises from sleep deprivation studies [Baumgartner and Meinhold, 1986;Kasper et al, 1988;Kaschka et al, 1989;Rao et al, 1989] when a further increase in TSH secretion was seen. This observation has led to the controversial interpretation that sleep may exert an inhibitory function on TSH secretion [Parker et al, 1987] or that sleep deprivation is a physiological stimulant of TSH .…”

Section: Introductionmentioning

confidence: 71%

Effects of Thyrotropin-Releasing Hormone on the Sleep EEG and Nocturnal Hormone Secretion in Male Volunteers

Hemmeter¹,

Rothe²,

Güldner³

et al. 1998

Neuropsychobiology

View full text Add to dashboard Cite

Various peptides including corticotropin-releasing hormone (CRH) exert selective effects on sleep structure and noctural secretions of cortisol and growth hormone (GH). In animal studies analeptic effects and sleep disturbances after thyrotropin-releasing hormone (TRH) administration have been observed; studies of endocrine function in depressed patients suggest a pathological activity of CRH and TRH as compared with that in healthy volunteers. As the role of TRH in the regulation of the sleep endocrine pattern in humans has not yet been clarified, we performed a study to examine the effects of pulsatile administration of TRH on the sleep EEG pattern and the nocturnal secretions of cortisol and GH in 7 healthy male subjects. The sleep EEG was recorded from 23.00 to 07.00 h, and blood samples were collected every 20 min from 20.00 to 07.00 h for the analysis of GH and cortisol concentrations during intravenous administration of placebo or 4 × 50 µg TRH at 22.00, 23.00, 24.00, and 01.00 h. In contrast to the well-known effects of CRH on the sleep endocrine pattern, TRH exerts only a weak effect on the sleep EEG which is reflected in a slight decrease in sleep efficiency associated with a trend to wakefulness during the night. Furthermore, after TRH administration, the cortisol rise appeared earlier, and a nonsignificant tendency to an increased secretion of cortisol during the first half of the night was found. The GH secretion did not differ significantly after application of TRH or placebo. The activating, albeit weak, effect of TRH on the sleep EEG and nocturnal cortisol secretion in healthy volunteers confirms and adds to the results previously observed in animals. On the basis of these findings, we surmise that TRH may contribute to the disturbed sleep continuity seen in depressed patients, probably acting as a cofactor of CRH in a synergistic manner.

show abstract

Total sleep deprivation and thyroid function in depression

Cited by 20 publications

References 10 publications

Serum Thyrotropin Concentrations and Bioactivity During Sleep Deprivation in Depression

Serum Thyrotropin Concentrations and Bioactivity During Sleep Deprivation in Depression

Effects of Tryptophan Depletion in Drug-Free Depressed Patients Who Responded to Total Sleep Deprivation

Effects of Thyrotropin-Releasing Hormone on the Sleep EEG and Nocturnal Hormone Secretion in Male Volunteers

Contact Info

Product

Resources

About