Total serum vitamin C concentration in pregnant women: implications for a healthy pregnancy

Hassan, Garba Ibrahim; Onu, Amodu Bala

doi:10.1590/s1519-38292006000300005

Cited by 15 publications

(14 citation statements)

References 22 publications

(23 reference statements)

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“…The levels of vitamin C observed in our study were similar to those reported by others [26] . Our results indicate that vitamin C may be one of the contributors to preterm delivery.…”

Section: Discussionsupporting

confidence: 92%

High Maternal Plasma Antioxidant Concentrations Associated with Preterm Delivery

et al. 2008

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Background/Aims: Our earlier study has shown that increased maternal oxidative stress and reduced antioxidants like vitamin E and C play an important role in fetal growth in preeclampsia. However, the role of antioxidants and their effects on gestation and birth outcome in normotensive pregnancies are not conclusive. The present study examined plasma malondialdehyde as a marker of oxidative stress and antioxidant concentrations (vitamins E and C) in maternal as well as in cord blood samples in normotensive women who delivered both preterm and at term. Methods: 140 normotensive pregnant women were recruited at Bharati Medical Hospital, Pune, India, during the year 2007. Maternal and cord samples were examined for oxidative stress levels and vitamin C and E concentrations in women who delivered preterm (n = 40) and at term (n = 100). Mean values were compared with those of women delivering at term using the t test. Results: Increased (p < 0.05) oxidative stress was seen in preterm mothers as well as in cord samples. Preterm mothers had higher vitamin C concentrations (p < 0.05), and these were positively associated with oxidative stress (p = 0.02). Vitamin E levels were comparable between groups. Conclusions: Increased maternal circulating vitamin C concentrations and increased oxidative stress are associated with preterm delivery.

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“…The levels of vitamin C observed in our study were similar to those reported by others [26] . Our results indicate that vitamin C may be one of the contributors to preterm delivery.…”

Section: Discussionsupporting

confidence: 92%

High Maternal Plasma Antioxidant Concentrations Associated with Preterm Delivery

et al. 2008

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“…This could be true because of inability of humans to synthesis vitamin C. In the present study, no significant changes in vitamin C levels were observed in both second and third trimesters of normal and pre-eclamptic pregnancies. This is contrary to the work of Luqman et al 2008 (14) and Hassan et al 2006 (25) who observed decreasing level of vitamin C as pregnancy advances, though their sample size was small and dietary exposure may be different. However, our observation can be the result of increasing gestational age which is usually accompanied with increase tissue demand of nutrients and increase appetite.…”

Section: Discussioncontrasting

confidence: 75%

Free Radical Attack on Membrane Lipid and Antioxidant Vitamins in the Course of Pre-Eclamptic Pregnancy

Atiba¹,

Abbiyesuku²,

Niran-Atiba³

et al. 2014

Ethiop J Health Sci

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BackgroundDespite the volume of knowledge and daily reports on pre-eclampsia, its pathogenesis is still yet to be ascertained. Oxidative stress (oxidant (free radical) in excess of antioxidant) injury is one of the recently suggested pathogenetic mechanisms. This study, however, was designed to determine second and third trimesters of plasma malondialdehyde (product of free radical attack on membrane lipid) and vitamins C and E in pre-eclamptic Nigerian women.Subjects and MethodsA Total of 100 subjects, each for pre-eclamptic, apparently normal and non-pregnant women qualified for the study. Venous blood samples were taken in the second and third trimesters of pregnancy and at the point of contact for non-pregnant women. Variables were analyzed using SPSS version 16, taking level of significance to be 0.05.ResultsPlasma malondialdehyde in the third trimester of normal pregnancy (2.03±0.71µmol/l) was found to be significantly higher than the one in the second trimester (1.65±0.62µmol/l) (p<0.0001). For pre-eclamptic subjects, the malondialdehyde in the third trimester (3.13±0.61µmol/l) was also higher than the malondialdehyde in the second trimester (3.00±1.21µmol/l). The mean vitamin C values for subjects with normal pregnancy were similar in the second and third trimesters (38.25±19.66 vs. 38.66±19.40; p=0.882). For subjects with pre-eclampsia, the mean Vit C values were also similar in the 2nd and 3rd trimesters (35.05±18.37 vs. 37.20±24.44µmol/l; p=0.175). Mean vitamin E values in the second and third trimesters were also similar for subjects with normal pregnancy (28.62±13.85 vs. 28.50±13.35µmol/l; p=0.950). A similar finding was observed in pre-eclamptic subjects (25.09±12.79 vs. 28.00±14.83µmol/l; p=0.067).ConclusionThere was an increased product of membrane lipid attack (malondialdehyde) with no change in plasma levels of vitamins C and E as pregnancy advances into the third trimester of both normal and pre-eclamptic pregnancies. Antioxidant vitamins may not be useful in stopping the progression of free radical attack on membrane lipid to control pre-eclampsia.

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“…En línea con lo anterior, ambos grupos de gestantes mostraron concentraciones más elevadas de MDA y un índice de EOx (MDA/AA) mayor respecto del grupo control de no embarazadas (adolescentes y adultas). Al igual que otros autores (5,17,18) Ruiz-Fernández N. y col.…”

Section: Discussionunclassified

Estudio exploratorio de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes atendidas en una consulta prenatal pública de la ciudad de San Felipe, Venezuela

Ruíz-Fernández¹,

Osuna²,

Mora³

et al. 2016

Rev Med Hered

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RESUMENLas adolescentes embarazadas constituyen un grupo de alta vulnerabilidad biológica y social. Objetivo: Evaluar el comportamiento de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes en el segundo y tercer trimestre de embarazo atendidas en una consulta prenatal pública y compararlo con el que muestran gestantes adultas y mujeres no embarazadas. Material y métodos: Estudio descriptivo transversal, que incluyó 29 gestantes adolescentes (14-20 años), 26 gestantes adultas (20-44 años) y 25 mujeres no embarazadas (17-44 años). Se determinó en suero malondialdehído (MDA), ácido ascórbico (AA), ácido úrico (AU), colesterol total (CT), LDLc, HDLc, triglicéridos (TGL) y se calculó el índice de estrés oxidativo (MDA/AA), relaciones CT/ HDLc, LDLc/HDLc, TGL/HDLc y colesterol NoHDL. Resultados: En ambos trimestres, las gestantes adolescentes mostraron valores más elevados de MDA, índice MDA/AA, TGL y relación TGL/HDLc así como concentraciones menores de AA, en comparación con adolescentes no embarazadas. Solo en el tercer trimestre, los niveles de CT y LDLc de las gestantes adolescentes superaron significativamente los encontrados en adolescentes no embarazadas. Los marcadores evaluados no variaron significativamente entre el segundo y tercer trimestre en las gestantes adolescentes. En el tercer trimestre, las concentraciones de MDA, LDLc y colesterol NoHDL de las gestantes adolescentes fueron significativamente menores respecto de las gestantes adultas. Conclusiones: El embarazo adolescente normal se asoció a modificaciones del estado redox y del metabolismo lipídico, especialmente en el tercer trimestre, pero no se confirmó que dichos cambios gestacionales fuesen de mayor magnitud respecto de las gestantes adultas.PALABRAS CLAVE: adolescente, embarazo, oxidación, ácido ascórbico, lípidos, ácido úrico. (Fuente: DeCS BIREME).

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Total serum vitamin C concentration in pregnant women: implications for a healthy pregnancy

Cited by 15 publications

References 22 publications

High Maternal Plasma Antioxidant Concentrations Associated with Preterm Delivery

High Maternal Plasma Antioxidant Concentrations Associated with Preterm Delivery

Free Radical Attack on Membrane Lipid and Antioxidant Vitamins in the Course of Pre-Eclamptic Pregnancy

Estudio exploratorio de marcadores plasmáticos del estado redox y perfil lipídico en gestantes adolescentes atendidas en una consulta prenatal pública de la ciudad de San Felipe, Venezuela

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