Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas

Rengganis, Iris; Rambe, Dirga Sakti; Rumende, Cleopas Martin; Abdullah, Murdani

doi:10.13181/mji.v27i4.2910

Cited by 5 publications

(6 citation statements)

References 17 publications

(16 reference statements)

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“…These inflammatory mediators promote further constriction of airways by causing excessive mucus secretion (31). The results of the present study are in agreement with previous results; significantly elevated levels of IgE antibodies were observed amongst the asthmatic patients compared with the healthy individuals (3,32,33). The results of the present study showed a significant association between the rs20541 SNP of IL-13 and total IgE serum levels, in which pure minor alleles were significantly associated with reduced IgE serum levels (~5x lower) compared with major alleles in asthmatic subjects.…”

Section: Discussionsupporting

confidence: 93%

IL‑13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients

2021

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Immunoglobulin E (IgE) serves a crucial role in the pathogenesis of several allergic disorders, and elevated levels of total serum IgE have been associated with asthma. IgE is responsible for the release of several asthma-associated inflammatory mediators from mast cells, such as histamine and prostaglandins. The aim of the present study was to assess the association of interleukin (IL)-13 single nucleotide polymorphism (SNP) rs20541 and forkhead box O3a (FOXO3a) SNP rs13217795 with IgE levels in asthmatic patients and a healthy control group. Genetic polymorphism analysis of SNPs was performed using PCR/restriction fragment length polymorphism. Total serum IgE levels were measured using an ELISA kit. Genotypes were grouped into three models: Co-dominant, dominant and recessive. Major and minor alleles for IL-13 SNP rs20541 and FOXO3a SNP rs13217795 were C and T, whereas for IL-13, they were G and A, respectively. There was a significant association between the IL-13 rs20541 SNP and the total IgE serum levels, in which pure minor alleles were associated with a significant reduction (~5x lower) in IgE serum levels compared with the major alleles in asthmatic subjects and to a lesser extent in the control subjects. Additionally, the FOXO3a rs13217795 SNP was associated with a significant increase in total IgE levels (~5x higher) in the asthmatic patients compared with the control subjects. In conclusion, the present study confirmed that there was a significant association between the IL-13 SNP rs20541 and asthma, and an association between the FOXO3a SNP rs13217795 with asthma pathogenicity in Jordanian subjects.

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Section: Discussionsupporting

confidence: 93%

IL‑13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients

2021

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“…The average IgE concentration in HBRA was 430.72 IU/ml and in NBRA it was 283.59 IU/ml. It was known that the average levels of IgE in the resident of both regions are above normal value (1.5-144 kU/l), according to Rengganis et al [21]. Analysis of IgE with Mann whitney U test showed higher average values in exposed persons compared to controls and statistically significant (P=0.0482).…”

Section: Resultsmentioning

confidence: 90%

“…The IgE concentration in males was significantly higher than females in both populations (P<0.05). The study on IgE concentration in Western European countries showed the total reference range of IgE as normal in young adults is 95 th percentile of the total IgE reference value (148 IU/ml in women, 169 IU/ml in men) [21]. It was also noted that a high concentration of IgE in male is associated with smoking habits [23].…”

Section: Resultsmentioning

confidence: 99%

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

et al. 2022

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The immune system is one of the most significant defenses against environmental insults including natural radiation. The purpose of this preliminary study was to assess the effects of high natural radiation to Mamuju residents, by focusing on immune-related blood cell counts (leukocytes, lymphocytes, monocytes, and granulocytes) and immunoglobulin E (IgE) level. The blood samples were collected from 18 adult residents in a high background radiation area (HBRA) while 18 residents in a normal background radiation area (NBRA) served as a control group. The blood components were measured by using the hematopoietic analyzer, and IgE immune biomarker was measured with ELISA (enzyme-linked immunosorbent assay) according to standard protocols. The data showed that the level of all blood cells, except for monocytes, of residents in HBRA was higher than that of NBRA. Statistical analysis revealed that there was no significant difference (P>0.05) in the blood cell counts and IgE level in both groups and their values were within normal limits. The level of IgE in HBRA was significantly higher than the control area (P≤0.05), as its IgE level in males compared to females in both residents. The relationship between IgE level and age were negative in these residents. From this study, it was concluded that long-term exposure to high radiation may affect the immune system as one of radiation adaptive response.

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“…The tools for assessing asthma severity are not consistent among studies and different guidelines recommend using different methods to identify asthma severity e.g., the Global Initiative for Asthma (GINA) criteria classifies asthma as mild, moderate, and severe while National Institute of Health in USA (NIH) classifies it as intermittent and persistent. 22 Most patients with asthma have a mild or moderate disease and data on the prevalence of severe asthma is sparse but reports indicate between 5 and 10% of the asthmatic populations to have had severe disease. 23 In this study, the method used for classifying asthma severity incorporated patient's symptoms into pulmonary function test but the main parameter was the results of FEV1 which made the results of pulmonary function tests statistically significantly different among the different asthma severity groups.…”

Section: Discussionmentioning

confidence: 99%

Relationship between pulmonary function tests, sputum eosinophilia and total serum IgE levels among asthmatic patients in Duhok, Iraq

et al. 2020

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Background: Bronchial asthma is a disease characterized by reversible airway obstruction, airway inflammation; and hyper-responsiveness. The prevalence of asthma is high, and both its prevalence and burden have increased over the last several decades. The study of inflammatory markers has implications for the appropriate management of this disease. Inflammatory markers has implications for the appropriate management of this disease. Objective of the study is to determine the correlation between asthma severity using pulmonary function tests with sputum eosinophilia and total serum IgE levels.Methods: This case-control study was conducted from March 2017 to September 2018 in the respiratory unit of Azadi general teaching hospital. It included 42 asthmatic patients and 18 healthy subjects. They underwent pulmonary function tests and measurement of total serum IgE levels. Induced sputum was done for asthmatic patients.Results: The age of asthmatic patients ranged from 16-70 years (mean 42±19 years). The asthmatic patient’s female: male ratio was 1.8. Mild asthma was the most common severity group (N=18, 43%) followed by moderate asthma (N=14, 33%) then severe asthma (N=10, 24%). Abnormal sputum eosinophilia (≥3%) was detected in 90% of severe asthma (N=9) compared to 36% in moderate asthma (N=5) and 5.6% in mild asthma (N=1). There was significant statistical association between asthma severity and sputum eosinophilia (p=0.00004). The association between asthma severity and total serum IgE levels was highly significant (p<0.0000) with levels of total serum IgE increasing as the severity of asthma increases.Conclusions: Severe asthma is the least common severity group in this study. Both abnormal sputum eosinophilia and total serum IgE levels are associated with the severity of asthma.

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Total serum IgE levels among adults patients with intermittent and persistent allergic asthmas

Cited by 5 publications

References 17 publications

IL‑13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients

IL‑13 and FOXO3 genes polymorphisms regulate IgE levels in asthmatic patients

The Effects of High Level Natural Radiation in Mamuju - Indonesia on the Immune System of Its Residents

Relationship between pulmonary function tests, sputum eosinophilia and total serum IgE levels among asthmatic patients in Duhok, Iraq

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