Total Serum IgE Concentrations in Adolescents and Adults Using the Phadebas IgE PRIST® Technique

Abstract

Total serum IgE measured with the Phadebas PRIST technique was titrated in 117 normal non-allergic subjects, 237 allergic adolescents or adults and 89 non-allergic patients who suffered from asthma, rhinitis, or conjunctivitis. All subjects were of Caucasian origin. In normal subjects, mean total serum IgE was 38 +/- 43 kU/l. This value is exactly the same as that found in a study of Caucasian New Zealanders and very similar to the values found in most U.S. studies. This suggests that the mean total serum IgE concentration is remarkably constant in normal non-allergic Caucasians. The upper limit of the normal range is considered to be 150 kU/l. 38% of allergic patients have total IgE concentrations within the normal range. Some pollen or hymenoptera venom-sensitive patients have a total serum IgE concentration below 20 kU/l. The non-allergic patients had a mean IgE concentration of 94 +/- 93 kU/l, and 25% of them had a total serum IgE above the normal range. Asthmatic patients had higher mean IgE levels than those who were suffering from either rhinitis or conjunctivitis.

The Po River Delta Respiratory Epidemiological Survey: an analysis of factors related to level of total serum IgE

“…This finding confirms observations made in Tucson, USA [5] and in Greece [19], whereas it is in contrast with other studies [4,20,26]. Recently, JARVIS et al [8] have found, in a stratified random sample of 20-44 yr old subjects living in East Anglia, that, among nonsmokers, geometric mean total IgE was higher in males than females.…”

Total Serum Immunoglobulins and Atopic Symptoms in Patients with Vitiligo

“…Interestingly, atopic patients with vit iligo showed a tendency to normal IgE levels, as 55.6% had IgE values in the normal range. Most of the recent studies using the PRIST technique with a cutoff level of 100 kU/1 showed normal IgE values in about 20% of atopic subjects (table I) [21,29,32]. Our results correlated with those of Przybilla et al [34].…”

CCL23 Expression Is Induced by IL-4 in a STAT6-Dependent Fashion

“…Based on the moderate sensitivity of the ELISA, it is quite possible that the percentage of donors containing biologically relevant concentrations of CCL23 is much higher than 26%. Serum IgE levels higher than 100 kU/L serve as one of several parameters indicative of atopy in adults (37). Thus, the same plasma samples were analyzed for IgE concentrations (Table I).…”