Total Serum Calcium Level Is Negatively Correlated With Systemic Lupus Erythematosus Activity

Sha, Yeqin; Rui, Zhilian; Dong, Yulan; Wei, Xiao‐Hong; Zhou, Yuning; Ye, Xiaoxue; He, Lianping; Shi, Dongyan

doi:10.1177/1559325820926764

Cited by 5 publications

(7 citation statements)

References 37 publications

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“…In a similar manner, the renal processing of phosphorus can modify its capacity in order to fulfil the requirements of cells for phosphorus. As confirm with previous study, patients with SLE had decreased serum calcium compared to healthy controls (93). The result showed that serum calcium reduced in mice lacking…”

Section: Chapter V Disscussionsupporting

confidence: 91%

Effects of lipopolysaccharide on mandibular and tibial bone regenerationin a murine model of SLE induced by Fc?RIIB deficiency

Jantaboon

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Although systemic lupus erythematosus (SLE) is known as the autoimmune disease that triggers inflammation and bone impairment, the mechanisms leading to the decrease in bone regeneration remain inadequately characterized. Patients with SLE have been observed high prevalence in bone loss due to host immune responses that may induce host antimicrobial activities. Here, this study used systemic and local lipopolysaccharide (LPS) administration for mimicking infectious condition in Fc?RIIB?/? mice as a lupus murine model. The results showed Fc?RIIB lacking Fc?RIIB?/? in mice with local and systemic LPS led to decreased cancellous bone volume in their drilled hole region of tibial and mandibular bone compared to WT, Fc?RIIB?/?, and WT+LPS groups. Likewise, the data of aniline blue staining in histological analysis showed a decrease of mineralization/collagen ratio in Fc?RIIB-deficient activated by local and systemic LPS compared to others. Deleting Fc?RIIB with LPS administration increased osteoclast gene expression but decreased osteoblast gene expression indicating the reduction of bone regeneration. Moreover, serum TNF-?, IL-6, and MCP-1 level was high in Fc?RIIB?/?+ LPS mice. The induction of proinflammatory cytokines may cause LPS-induced osteoclast formation and a decrease in osteoblasts that have an important role in collagen production. Herein, LPS administration could suppress bone regeneration and collagen accumulation in cancellous bone of mandible and tibia of mice with Fc?RIIB deletion by increasing serum proinflammatory cytokines.

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Section: Chapter V Disscussionsupporting

confidence: 91%

Effects of lipopolysaccharide on mandibular and tibial bone regenerationin a murine model of SLE induced by Fc?RIIB deficiency

Jantaboon

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“…7 Besides, total blood calcium level is negatively correlated with systemic lupus erythematosus activity. 18 In this study, we found that postoperative bleeding decreased with increasing levels of blood calcium, implying that to some extent, blood calcium concentration levels may be associated with postoperative bleeding in cardiac surgery patients. We found there was a significant difference in blood albumin concentration preoperatively and patients with hypocalcemia have lower albumin levels.…”

Section: Discussionmentioning

confidence: 56%

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

Dai

Zhou

et al. 2022

Perfusion

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Introduction Bleeding after heart valve surgery is a serious clinical challenge. Hypocalcemia has been associated with the extent of bleeding in patients with spontaneous intracerebral hemorrhage. However, the association between blood calcium levels and bleeding extent in heart valve replacement patients has not been clearly established. This study aimed at determining the association between blood calcium levels and perioperative hemorrhage after heart valve replacement therapy. Methods Based on preoperative blood calcium levels, patients were grouped into the hypocalcemia group and normocalcemia group. Postoperative bleeding, blood product use, and complications were monitored during hospitalization. The association between blood calcium levels and major bleeding was determined by multivariable logistic regression models. Results In the first 12 h after surgery, bleeding in hypocalcemia group was significantly larger than that of the normocalcemia group (338 ± 234 mL vs 232 ± 96 mL; p = .024). The outcome was the same when the overall chest tube output was considered (950 ± 447 mL vs 738 ± 220 mL; p = .038). The incidence of major bleeding was 65.91% in the hypocalcemia group and 18.97% in the normocalcemia group ( p = .001). Postoperative complications in the two groups were similar. After adjusting for multiple covariates, the adjusted odds ratios (OR) for participants in hypocalcemia group was 10.01 (95% CI 3.35–34.82), compared with that in normocalcemia group ( p < .001). Conclusion In patients undergoing heart valve surgery, preoperative blood concentrations of calcium are associated with postoperative blood loss. Hypocalcemia before operation may increase the risk of postoperative bleeding. When patients with valvular heart disease present with hypocalcemia before surgery, prompt intervention may lead to better control of postoperative bleeding.

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“…Calcium levels may be more important in the SLE disease process than previously thought. Hypocalcemic events are more common in SLE patients [23]. As a result, changes in total serum calcium levels in our study SLE patients could have contributed to the drop in serum albumin level [23].…”

Section: Resultsmentioning

confidence: 64%

The Impact of Some Biochemical Factors in Increasing Disease Pathogenicity of Systemic Lupus Erythematosus

Kuba,

Ahmed

2023

Iraqi Journal of Science

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Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown etiology, though genetic and environmental factors appear to play a role in its pathogenesis. In particular, infectious processes are linked to the onset and exacerbation of SLE. The aim of the current study was to understand the relationship between some biochemical factors in SLE patients. 105 blood samples from both genders were collected. ELISA technique was used for detecting specific procalcitonin, vitamin D and calcium. The results of this study showed that SLE patients recorded the lowest percentages of calcium (7.36 ± 0.10 mg/dl) than control (11.97 ± 2.12 mg/dl), and vitamin D (7.79 ± 0.58 pg/ml) than control (22.10 ± 4.83 pg/mL). And the highest percentage of procalcitonin level in serum (35.73 ± 4.08 pg/ml) compared to the control (11.57 ± 5.35 pg/ml). Furthermore, the seroprevalence of SLE patients was the highest in the 31-45 years age group, and the majority of them were females which accounted 87.5 %. In this study vitamin D and calcium were the lowest in SLE patients. The severity of disease symptoms in SLE patients may be caused by specific alterations in vitamin D and calcium homeostasis. And procalcitonin was the highest in SLE patents.

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Total Serum Calcium Level Is Negatively Correlated With Systemic Lupus Erythematosus Activity

Cited by 5 publications

References 37 publications

Effects of lipopolysaccharide on mandibular and tibial bone regenerationin a murine model of SLE induced by Fc?RIIB deficiency

Effects of lipopolysaccharide on mandibular and tibial bone regenerationin a murine model of SLE induced by Fc?RIIB deficiency

The association between preoperative blood calcium and postoperative blood loss in patients undergoing heart valve replacement surgery

The Impact of Some Biochemical Factors in Increasing Disease Pathogenicity of Systemic Lupus Erythematosus

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