Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells

Zhang, Yin-Yu; Luo, Lin-Ming; Wang, Yuxiang; Zhu, Neng; Zhao, Tanjun; Qin, Li

doi:10.7150/jca.42285

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…However, in Korea, the bulbs of JD are used to treat bronchitis, pneumonia, and so on [ 28 ]. JD bulbs are also reported to possess potent antioxidant and anticancer characteristics [ 8 , 29 ]. Other medicinal effects of JD remain to be studied.…”

Section: Resultsmentioning

confidence: 99%

Metabolome-Based Discrimination Analysis of Five Lilium Bulbs Associated with Differences in Secondary Metabolites

et al. 2021

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The bulbs of several Lilium species are considered to be both functional foods and traditional medicine in northern and eastern Asia. Considering the limited information regarding the specific bioactive compounds contributing to the functional properties of these bulbs, we compared the secondary metabolites of ten Lilium bulb samples belonging to five different species, using an ultrahigh-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UPLC-ESI-MS/MS)-based secondary metabolomics approach. In total, 245 secondary metabolites were detected; further, more metabolites were detected from purple Lilium bulbs (217 compounds) than from white bulbs (123–171 compounds). Similar metabolite profiles were detected in samples within the same species irrespective of where they were collected. By combining herbal analysis and screening differential metabolites, steroid saponins were considered the key bioactive compounds in medicinal lilies. Of the 14 saponins detected, none were accumulated in the bulbs of L. davidii var. willmottiae, also called sweet lily. The purple bulbs of L. regale accumulated more secondary metabolites, and, notably, more phenolic acid compounds and flavonoids. Overall, this study elucidates the differential metabolites in lily bulbs with varying functions and colors and provides a reference for further research on functional foods and the medicinal efficacy of Lilium species.

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Section: Resultsmentioning

confidence: 99%

Metabolome-Based Discrimination Analysis of Five Lilium Bulbs Associated with Differences in Secondary Metabolites

et al. 2021

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“…Studies have shown that the underground bulbs are rich in various bioactive substances, such as total phenols, total flavonoids, polysaccharides, and saponins [2,3], which contribute to the quality and nutritional value. These compounds are known to have antitumor [4,5], anti-oxidation [6,7], hypoglycemic [8], and anti-inflammatory functions [9,10]. The bulb is an important vegetative reproductive organ for triploid L. lancifolium.…”

Section: Introductionmentioning

confidence: 99%

Effects of Applying Nitrogen and Potassium on Lilium lancifolium Growth and Accumulation of Secondary Metabolites in Bulbs

Wang

Zhang

et al. 2023

Horticulturae

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Lilium lancifolium is a plant resource used as both medicine and food because it is enriched with polysaccharides, polyphenol compounds, and saponins. Increasing the quality of Lilium species is based largely on improvement using methods such as selective breeding and proper fertilization. In this study, we investigated the different responses of L. lancifolium bulbs to treatment with nitrogen (N) and potassium (K) in Hoagland solution. A pot experiment was conducted with four N rates and five K rates under a completely random design. The agronomic traits, N and K contents, and concentrations of active compounds were determined in bulbs, including total phenols, flavonoids, polysaccharides, and saponins. L. lancifolium treated with N and K exhibited increases in the plant height, leaf number, and chlorophyll content compared with the control (N0 + K0). The bulb circumference increased by 17.41% under N2 (609.80 mg L−1) + K2 (523.34 mg L−1) compared with N0 + K0. Individual or combined application of N and K increased the total phenol, flavonoid, and saponin contents, especially under N2 + K3, with the highest increases of 1.87–2.93 times compared with N0 + K0. However, the individual application of N decreased the polysaccharide contents by 2.78–42.04%. Hoagland solution containing 443.24–572.87 mg L−1 N and 573.61–759.16 mg L−1 K is recommended to improve the active contents of bulb components based on regression analysis. Our results demonstrate that the combined application of N and K is important for obtaining high-quality L. lancifolium bulbs.

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Two New Isospirostanol‐Type Saponins from the Bulbs of Lilium Brownii and Their Anti‐Hepatocarcinogenic Activity

He,

Wu,

et al. 2024

Chemistry & Biodiversity

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Bulbs ofLilium brownii, commonly known as "Bai‐he" in China, serve both edible and medicinal purposes in clinical practice. In this study, two new isospirostanol‐type saponins were isolated from L. brownii, and their structures were identified by spectroscopic method, and absolute configurations were elucidated by comprehensive analysis of spectral data obtained from combined acid hydrolysis. Two compounds were finally identified as 3‐O‐[α‐L‐rhamnopyranosyl‐(1→2)‐β‐D‐glucopyranoside]‐(22R,25R)‐5α‐spirosolane‐3β‐ol (1) and 3‐O‐{α‐L‐rhamnopyranosyl‐(1→2)‐[β‐D‐glucopyranosyl‐(1→4)]‐β‐D‐glucopyranoside}‐(22R,25R)‐5α‐spirosolane‐3β‐ol (2), respectively. Further, we found that compound 2 significantly suppressed the proliferation of SMMC‐7721 and HepG2 cells with IC50 values of 26.3±1.08 µM and 30.9±1.59 µM, whereas compound 1 didn’t inhibit both of the two hepatocellular carcinoma. Subsequently, compound 2 effectively decreased the levels of interleukin‐1β and tumor necrosis factor‐α and the expression of Bcl‐2, and increased the expression of Bax and Caspase‐3 proteins. Which indicated that the anti‐hepatocellular carcinoma effect of compound 2 involves reducing the level of inflammation and inducing apoptosis.

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Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells

Cited by 6 publications

References 34 publications

Metabolome-Based Discrimination Analysis of Five Lilium Bulbs Associated with Differences in Secondary Metabolites

Metabolome-Based Discrimination Analysis of Five Lilium Bulbs Associated with Differences in Secondary Metabolites

Effects of Applying Nitrogen and Potassium on Lilium lancifolium Growth and Accumulation of Secondary Metabolites in Bulbs

Two New Isospirostanol‐Type Saponins from the Bulbs of Lilium Brownii and Their Anti‐Hepatocarcinogenic Activity

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