Total Replacement of Urethral Mucosa with Oral Mucosa in Dogs

Iizuka, Kojiro; Muraishi, Osamu; Maejima, Toshitaka; Kitami, Yoshihiro; Xu, Yuhong; Watanabe, Kenji; Ogawa, Akimi

doi:10.1097/00005392-199608000-00070

Cited by 6 publications

(9 citation statements)

References 7 publications

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“…[21] Subsequently, other publications focused on techniques of harvesting the graft, as well as the available sites that could avoid or minimize donor site morbidity. [1,[20][21][22][23][24][25][26][27] This led Filipas et al, to attest to the long-term suitability of mucosal grafts after exposure to urine. [3] The period from the late 1990s to the present times has seen more articles focusing on donor site morbidity in cases of oral mucosal grafts and its implications.…”

Section: Historical Perspectivementioning

confidence: 99%

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Oral mucosa grafts for urethral reconstruction

Mungadi

Ugboko

2009

Ann Afr Med

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Background: Urethral reconstruction has continued to present formidable and enormous challenges for urologic, paediatric and plastic surgeons as diverse opinions have been expressed on the quality and type of ideal substitution material. This literature review is aimed at drawing attention of surgeons to the versatile nature of oral mucosal grafts. Methods: A review of the utilization of oral mucosa in urethral reconstruction was made. Structured Medline search was performed looking at all aspects of utilization of oral mucosa including mucosal harvest, donor site morbidity and outcome. Results: The unique demands of the urethra set a high standard for autogenous graft substitutes; hence literature reports reveal that split and full thickness skin grafts from the scrotum, penis, extragenital sites (ureter, saphenous vein, appendix, colon, medial upper arm, neck, lateral chest, abdomen, bladder mucosa) and more recently oral mucosa have been used. Unlike other tissues, oral mucosa grafts are fl exible, easy to harvest and trim and have an excellent microvasculature favorable for graft-taking. Furthermore, the natural moist location of the oral mucosa in the oral environment favours its easy adaptability in the urethral passage thus giving good long-term results. However, there are reports of complications at the donor site with the commonest being anaesthesia or paraesthesia of the cheek or lips. Regional variations of the oral mucosa, length of the graft required, the decision to close or leave donor site open and harvesting technique are some of the factors suggested to account for differences in donor site morbidity. Conclusion: Oral mucosal graft is a versatile urethral substitute with excellent outcome. It is becoming the gold standard for urethral substitution.

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Section: Historical Perspectivementioning

confidence: 99%

“…Tolstunov and Pogrel [23] 1996 Wessells and McAninch [24] 1996 Lopez et al [25] 1996 Iizuka et al [26] 1997 Eppley et al [1] 1998 Filipas et al [3] Long-term suitability after exposure to urine 2003 Dublin and Stewart [28] Donor site morbidity and its implications 2004 Fichtner et al [29] 2004…”

Section: Historical Perspectivementioning

confidence: 99%

Oral mucosa grafts for urethral reconstruction

Mungadi

Ugboko

2009

Ann Afr Med

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“…For example, in 1996 Iizuka et al [31]reported an animal experiment in which complete urethral replacement was carried out in a dog model. The clinical imperative trageted by the experimental design was to replace the entire urethra in patients with bladder carcinomas, following radical cystectomy and urethrectomy.…”

Section: Introductionmentioning

confidence: 99%

History of Oral Mucosa

1998

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“…Relatos sugerem que implantes uretrais em retalho apresentam resultados melhores do que os tubulares no tocante à gênese das fístulas6,17 .A análise histológica das amostras coletadas aos 60 dias de observação mostrou presença de revestimento epitelial nos fragmentos do canal uretral, evidenciando infiltrado inflamatório de neutrófilos, linfócitos piócitos e histiócitos. Estes resultados sugerem inflamação, o que também foi observado por Iizuka e col 5. .…”

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Uretroplastia de substituição com segmentos tubulares autólogos de mucosa bucal em cães

et al. 2003

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OBJETIVO: Avaliar a reconstrução de defeitos experimentais na uretra do cão com a implantação de segmentos tubulares de mucosa bucal autóloga. MÉTODOS: Procedeu-se à ressecção de cerca de 2 cm da uretra peniana de 20 cães. O defeito produzido foi corrigido por meio da anastomose de fragmento tubular de mucosa bucal autóloga, seccionado do lábio inferior. RESULTADOS: Entre os animais operados, 14 (70%) apresentaram jato urinário normal e seis (30%) evidenciaram estenose confirmada por meio de exame radiológico realizado aos 60 dias do pós-operatório. Durante a necrópsia verificou-se a integridade dos implantes no sulco uretral, associado a infiltrado inflamatório de neutrófilos, linfócitos piócitos e histiócitos. As análises histológicas revelaram que os fragmentos implantados estavam recobertos pelo epitélio uretral. CONCLUSÃO: A implantação de segmentos autólogos de mucosa bucal é adequada para a reconstrução de defeitos uretrais iatrogênicos no cão, embora possa resultar em estenose pós-operatória.

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Total Replacement of Urethral Mucosa with Oral Mucosa in Dogs

Abstract: These results indicate that the urethral mucosa can be replaced by oral mucosa without damaging the continence mechanism in female dogs.

Cited by 6 publications

References 7 publications

Oral mucosa grafts for urethral reconstruction

Oral mucosa grafts for urethral reconstruction

History of Oral Mucosa

Uretroplastia de substituição com segmentos tubulares autólogos de mucosa bucal em cães

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