Total replacement of blood by an emulsion of fluorocarbon in the rat-water extravasation as a cause of failure

Fournier, Geneviève; Barrois, V.; Girard, Charlotte; Robert, D; Foulletier, L

doi:10.1007/bf01965805

Cited by 7 publications

(1 citation statement)

References 2 publications

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“…It has been reported that Fluosol haemodilution in rats caused a one-third reduction in the circulating blood volume after 3 h, and the blood volume remained depressed for 24 h (Matsumoto et al 1977;Watanabe et al 1979). In anaesthetized rats, hypovolaemia was produced as water transfers from the vascular to the interstitial fluid (Fournier et al 1980), but the driving force for the water transfer was not determined. There is no reported information on whether the hypovolaemia persists longer than 24 h, or if saline haemodilution would cause a similar effect.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Varying Percentages of Haemodilution with Fluosol-DA or Normal Saline on Antipyrine Metabolism in the Rat

Shrewsbury

Oliver

Anderson

et al. 1988

Journal of Pharmacy and Pharmacology

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Antipyrine disposition and metabolism in conscious, unrestrained rats after 25 or 50% haemodilution with Fluosol or normal (0.9% NaCl) saline is reported. Rats received an intravenous antipyrine dose (20 mg kg-1) 0.5, 24, 48, or 72 h after haemodilution and its pharmacokinetic parameters have been compared with non-exchanged control animals. Haemodilution 25% with Fluosol initially depressed antipyrine metabolism for 24 h by decreasing the antipyrine urinary excretion rate constant and the formation rate constants of 4-hydroxyantipyrine (4-OH) and 3-hydroxymethylantipyrine (3-OHME). Metabolism was then increased for 48 and 72 h with a slight increase in all rate constants. Haemodilution 50% with Fluosol produced a similar pattern but with significant increases in the 3-OHME formation rate constant found at 48 and 72 h. Haemodilution 25% with saline reduced 4-OH formation for 48 h. Haemodilution 50% with saline significantly reduced antipyrine urinary excretion at all times. After a significant increase in the 4-OH and 3-OHME formation rate constants at 24 h following 50% haemodilution with saline, the rate constants were significantly decreased at 48 and 72 h. Haemodilution 25% with Flusol significantly reduced the antipyrine Vd at 0.5 and 72 h. After haemodilution 50% with Fluosol, the Vd alternated between values greater and less than control throughout the 72 h. Haemodilution 25 or 50% with saline had little influence on Vd.

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Section: Discussionmentioning

confidence: 99%

The Effect of Varying Percentages of Haemodilution with Fluosol-DA or Normal Saline on Antipyrine Metabolism in the Rat

Shrewsbury

Oliver

Anderson

et al. 1988

Journal of Pharmacy and Pharmacology

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Changes in intravascular fluid composition following blood replacement with perfluorocarbon emulsion in the rat

Lowe

McNaughton

1985

Klin Wochenschr

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The effects of near total blood replacement with the proprietary perfluorocarbon emulsion, Fluosol-DA, have been examined in conscious, chronically catheterized rats. Animals survived for up to 48 h with a haematocrit of less than 2%. No overt changes in cardiovascular or respiratory functions occurred during blood replacement but thereafter, animals showed a progressive deterioration of haemodynamic control. Changes in intravascular fluid composition during and following exchange-transfusion have been monitored and the extent to which these changes could have contributed to the eventual disruption of homeostasis is discussed.

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Acute physiological responses during blood substitution with colloidal gelatin in conscious rats

Lowe

McNaughton

1984

Experientia

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Total replacement of blood by an emulsion of fluorocarbon in the rat-water extravasation as a cause of failure

Cited by 7 publications

References 2 publications

The Effect of Varying Percentages of Haemodilution with Fluosol-DA or Normal Saline on Antipyrine Metabolism in the Rat

The Effect of Varying Percentages of Haemodilution with Fluosol-DA or Normal Saline on Antipyrine Metabolism in the Rat

Changes in intravascular fluid composition following blood replacement with perfluorocarbon emulsion in the rat

Acute physiological responses during blood substitution with colloidal gelatin in conscious rats

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