Total regression of hepatocellular carcinoma bone metastases, after liver transplantation, with sorafenib-everolimus

Abstract

How to cite this article: Giakoustidis D, Gargavanis AA, Salveridis N, Cholongitas E, Sinakos E, Papapolychroniadis K, Papanikolaou V. Total regression of hepatocellular carcinoma bone metastases, after liver transplantation, with sorafenib-everolimus. Hepatoma Res 2017;3:205-8.Hepatocellular carcinoma (HCC) represents the 5th commonest malignancy worldwide. Liver transplantation consist a radical and most efficient treatment for HCC. Tumor recurrence or metastases after liver transplantation is not uncommon. Hereby is presented a case of a patient transplanted for alcoholic liver disease and HCC and presented with bone metastases a few months later. Treatment with sorafenib and everolimus showed full regression of the metastases. In conclusion, the point of this report is to advertise a single case of total regression of bone lesions due to HCC recurrence, with the combination of mammalian target of rapamycin and sorafenib, along with radiation. Key words:Liver transplantation, hepatocellular carcinoma, bone metastases, sorafenib, everolimus ABSTRACTArticle history: