Total reference air kerma: To what extent can it predict intracavitary volume enclosed by isodose surfaces during multiple high-dose rate brachytherapy?

Datta, Niloy Ranjan; Das, K.J. Maria; Basu, R; Singh, Uttam

doi:10.1016/s1538-4721(03)00096-5

Cited by 10 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the lymphocytes do not stay in one organ, therefore in biodosimetric investigations such irradiated volumes should be used that are independent of the organs. In ve studies [19][20][21][22][23] total reference air kerma (TRAK) was compared with ISVs. The studies followed ICRU 38 recommendation [24] to use total reference air kerma for the dose and volume description in cervix brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

Kocsis¹,

Major²,

Pesznyák³

et al. 2021

Preprint

View full text Add to dashboard Cite

Brachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies, fractionation. However, the overall impact of these variables is neglected on the biological dose of blood. As the size of the irradiated volume also influences the biological effect, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V50Gy, V100%, V150%) and CAs in case of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs nine months after LDR BT, three months after HDR BT in a long time-range (even till one year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed.The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy in spite of the fractionation.

show abstract

Section: Discussionmentioning

confidence: 99%

Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

Kocsis¹,

Major²,

Pesznyák³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…However, the lymphocytes do not stay in one organ, therefore in biodosimetric investigations organ-independent irradiated volumes should be used. In five studies 19 – 23 total reference air kerma (TRAK) was compared with ISVs. The studies followed ICRU 38 recommendation 24 to use total reference air kerma for the dose and volume description in cervix brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

Relationship between biodosimetric parameters and treatment volumes in three types of prostate radiotherapy

Kocsis

Major

Pesznyák

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Brachytherapy (BT) and external beam radiotherapy (EBRT) apply different dose rates, overall treatment times, energies and fractionation. However, the overall impact of these variables on the biological dose of blood is neglected. As the size of the irradiated volume influences the biological effect as well, we studied chromosome aberrations (CAs) as biodosimetric parameters, and explored the relationship of isodose surface volumes (ISVs: V1%, V1Gy, V10%, V10Gy, V100%, V150%) and CAs of both irradiation modalities. We performed extended dicentrics assay of lymphocytes from 102 prostate radiotherapy patients three-monthly for a year. Aberration frequency was the highest after EBRT treatment. It increased after the therapy and did not decrease significantly during the first follow-up year. We showed that various types of CAs 9 months after LDR BT, 3 months after HDR BT and in a long time-range (even up to 1 year) after EBRT positively correlated with ISVs. Regression analysis confirmed these relationships in the case of HDR BT and EBRT. The observed differences in the time points and aberration types are discussed. The ISVs irradiated by EBRT showed stronger correlation and regression relationships with CAs than the ISVs of brachytherapy.

show abstract

“…In intracavitary brachytherapy, TRAK has been shown to correlate with volume enclosed by isodose surface (ISV). Accordingly, predictive mathematical expressions relating volume enclosed by isodose to TRAK and dose are suggested in literature [2][3][4][5][6][7].…”

Section: Purposementioning

confidence: 99%

Correlation of total reference air-kerma (TRAK) to prescription isodose surface volume in vaginal cylinder high-dose-rate brachytherapy

Yaparpalvi

Mehta

2021

jcb

View full text Add to dashboard Cite

Purpose: The purpose of this technical note was to investigate correlation of total reference air-kerma (TRAK) with volume enclosed by the prescription isodose surface in vaginal cylinder high-dose-rate (HDR) brachytherapy.Material and methods: Treatment plans of 175 gynecological cancer patients treated at our institution with iridium-192 ( 192 Ir) HDR brachytherapy using a single-channel vaginal cylinder applicator were retrospectively reviewed. Applicator size in diameter ranged from 20 mm to 40 mm. Treatment length ranged from 30 mm to 90 mm (median, 50 mm). Brachytherapy fractional dose was 5 Gy (Dose Ref ) prescribed to 5 mm distance from cylinder surface. Parameters TRAK (cGy), source activity during treatment (Ci), total treatment time (s), and prescription isodose surface volume ISV Ref (cm 3 ) were recorded from individual treatment plans. In each case, vaginal tissue volume (V VT ) enclosed by prescription isodose was calculated by subtracting cylinder volume enclosed by the prescription isodose from ISV Ref .Results: Total reference air-kerma correlated with the total volume enclosed by the prescription isodose via ISV Ref = 4768 × (TRAK/Dose Ref ) 1.47 . TRAK related linearly to the volume of vaginal tissue enclosed by the prescription dose via V VT = ((138.3 × TRAK) -8.2). Secondarily, TRAK related to the treatment time through time (s) = 882 (s/cGy) × TRAK (cGy), where 882 is (1/air-kerma strength) for 10 Ci apparent activity of 192 Ir source.Conclusions: The correlation of TRAK to the vaginal tissue volume encompassed by the prescription dose surface yields a useful predictive equation. The TRAK treatment time relationship enables quick verification of planned treatment time by knowing TRAK in any HDR brachytherapy application.

show abstract

Total reference air kerma: To what extent can it predict intracavitary volume enclosed by isodose surfaces during multiple high-dose rate brachytherapy?

Cited by 10 publications

References 13 publications

Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

Relationship between biodosimetric parameters and treatment volumes in three types of prostate radiotherapy

Correlation of total reference air-kerma (TRAK) to prescription isodose surface volume in vaginal cylinder high-dose-rate brachytherapy

Contact Info

Product

Resources

About