“…However, ADAM 12 has the best discriminatory efficiency early in the first trimester ( Table 2). In that respect, the marker behaves in a manner similar to PAPP-A (Spencer et al, 2002(Spencer et al, , 2003dChristiansen and Jaliashvili, 2003), ProMBP (Christiansen et al, 1999(Christiansen et al, , 2004 and SP1 (Qin et al, 1997).…”