Total polyphenolic content, antioxidant, cytotoxic, antidiabetic activities, and polyphenolic compounds of Sophora japonica grown in Egypt

Abdelhady, Mohamed; Kamal, Ahmed A. M.; Othman, Samir M.; Mubarak, Mohammad S.; Hadda, Taïbi Ben

doi:10.1007/s00044-014-1101-2

Cited by 26 publications

(16 citation statements)

References 62 publications

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“…Among these, EF was the strongest natural antioxidant and showed a slightly lower DPPH• and ABTS• + scavenging effect and higher •OH scavenging effects than those of ascorbic acid. In addition, the sample with the highest TFC showed lower IC 50 values, confirming that flavonoids are likely to contribute to the antioxidant activities of the CWCP extract, in agreement with the results obtained by others (Fu and others ; Jordán and others ; Abdelhady and others ). A correlation analysis revealed that TFC exhibited the strongest correlation with DPPH• scavenging activity ( R 2 = 0.9041, P < 0.05) and did not show a significant correlation ( P > 0.05) with the ABTS• + ( R 2 = 0.…”

Section: Resultssupporting

confidence: 91%

Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids

Pan

et al. 2016

Journal of Food Science

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The preparation, quantification, and characterization of flavonoid compounds from Chinese water chestnut peel (CWCP) flavonoid extract and ethyl acetate fraction (EF), n-butanol fraction, and water fraction were studied. Among these, EF showed the maximum free radical levels (IC values of 0.36, 0.40, and 0.37 mg/mL for DPPH•, ABTS• , and •OH, respectively), nitrite scavenging effects (IC = 1.89 mg/mL), and A549 cell inhibitory activities (IC = 776.12 μg/mL) with the highest value of total flavonoid content (TFC, 421.32 mg/g). Moreover, the contents of 8 flavonoids in this fraction were quantified using high-performance liquid chromatography, and fisetin, diosmetin, luteolin, and tectorigenin were the 4 major flavonoids with levels of 31.66, 29.91, 13.69, and 12.41 mg/g, respectively. Luteolin produced a greater inhibition of human lung cancer A549 cells (IC = 59.60 μg/mL) than did fisetin, diosmetin, and tectorigenin. Flow cytometry revealed that the cellular mechanisms of luteolin inhibition of A549 cells were achieved via the induction of cell proliferation arrest at G phase and apoptosis/necrosis. Our findings suggest that flavonoids are closely associated with antitumor, antioxidant, and nitrite scavenging effects of CWCP.

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Section: Resultssupporting

confidence: 91%

Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids

Pan

et al. 2016

Journal of Food Science

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“…According to the literature, 4-keto-pinoresinol was reported to be active against SK-Mel-2, B16F1, ovarian cancer SKOV-3, CaoV-3, and cervical cancer HeLa cell lines cycle [ 17 ]. Tamarixetin was previously reported to possess cytotoxic action against A-549 and HCC-44 lung adenocarcinoma cells, gastric carcinoma (AGS), skin melanoma (B16F10), brain carcinoma (C6), epitheliod cervix carcinoma (HeLa) cells, MCF-7 and HCT-116 cells [ 18 , 19 , 20 ]. Additionally, 3,4-dihydrozybenzoic acid was also reported to cause apoptosis on human breast cancer MCF-7 cell, lung cancer A-549 cell, HepG2 cell, cervix HeLa cell, prostate cancer LNCaP cell, and A549 human lung cancer [ 21 , 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells

et al. 2021

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Different extracts of the Bamboo shoot skin Phyllostachys heterocycla var. pubescens were screened against panel of cancer cell lines and normal one. The cell viability results exhibited that the ethyl acetate extract showed the least vitality percentage of 2.14% of HepG2 cells. Accordingly, it was subjected to chromatographic separation, which resulted in the isolation of a new natural product; 7-hydroxy, 5-methoxy, methyl cinnamate (1), together with four known compounds. The structures of the pure isolated compounds were deduced based on different spectroscopic data. The new compound (1) was screened against the HepG2 and MCF-7 cells and showed IC50 values of 7.43 and 10.65 µM, respectively. It induced apoptotic cell death in HepG2 with total apoptotic cell death of 58.6% (12.44-fold) compared to 4.71% in control by arresting cell cycle progression at the G1 phase. Finally, compound 1 was validated as EGFR tyrosine kinase inhibitor in both enzymatic levels (IC50 = 98.65 nM compared to Erlotinib (IC50 = 78.65 nM). Finally, in silico studies of compound 1 through the molecular docking indicated its high binding affinity towards EGFR protein and the ADME pharmacokinetics indicated it as a drug-like.

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“…[2] The extract of FFB-SJ also has excellent potential as a yellow pigment in the food industry due to its natural yellow color and good thermal stability. [3] Previous pharmacological studies and clinical practice have demonstrated that FFB-SJ has anti-inflammatory, [4 -6] anti-obesity, [7] antitumor, [8] antidiabetic, [9] antioxidant [10,11] and tyrosinase-inhibiting activities, [12,13] and cardioprotective actions. [14] FFB-SJ can reduce brain damage caused by cerebral stroke.…”

Section: Introductionmentioning

confidence: 99%

Variations in the Components and Antioxidant and Tyrosinase Inhibitory Activities of Styphnolobium japonicum (L.) Schott Extract during Flower Maturity Stages

Wang

Tan

et al. 2019

Chemistry & Biodiversity

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Styphnolobium japonicum (L.) Schott is widely cultivated in China, and its flowers and flower buds (FFB‐SJ) are commonly used as traditional Chinese medicine. This work aimed to assess variations in the chemical components and antioxidant and tyrosinase inhibitory activities of S. japonicum extract during five flower maturity stages (ES1–ES5). The results showed that the contents of total flavonoids, rutin, and narcissin were highest at ES1, whereas the contents of quercetin and isorhamnetin were highest at ES3. ES1 presented considerable antioxidant activities in terms of reducing power (RP) and 1,1‐diphenyl‐2‐picrylhydrazyl radical (DPPH.) and hydroxyl radical (.OH) scavenging capacity, whereas ES3 showed excellent tyrosinase inhibitory activity and 2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid) radical (ABTS.+)‐ and O2.−‐scavenging capacity. Rutin and quercetin are the main bioactive components of FFB‐SJ with antioxidant and tyrosinase inhibition, and the immature flower buds of S. japonicum (S2 and S3) with excellent biological activities and relatively high extract yields were the best for product development.

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Total polyphenolic content, antioxidant, cytotoxic, antidiabetic activities, and polyphenolic compounds of Sophora japonica grown in Egypt

Cited by 26 publications

References 62 publications

Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids

Antitumor, Antioxidant, and Nitrite Scavenging Effects of Chinese Water Chestnut (Eleocharis dulcis) Peel Flavonoids

Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells

Variations in the Components and Antioxidant and Tyrosinase Inhibitory Activities of Styphnolobium japonicum (L.) Schott Extract during Flower Maturity Stages

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