Total Phenolic Content, Antioxidant and Antibacterial Properties of Scurrula ferruginea Extracts

Abstract

Discovery of new therapeutic agents from nature, especially plants is one of the promising approaches for treatment of various diseases. In traditional medicine Scurrula ferruginea is applied to treat some disorders. To the best of our knowledge, there are no investigations on antioxidant capacity and antimicrobial activities of S.ferruginea in Malaysia. The present study was conducted to determine total phenolic content, Fe2+ chelating activity, antioxidative and antimicrobial potential of flowers, leaves and stems of S.ferruginea extracts. Antioxidant capacity, and total phenolic content of extracts were evaluated using DPPH free radical scavenging and Folin-Ciocalteu assays. Antibacterial properties were evaluated by disc diffusion, minimum inhibitory concentration and minimum bactericidal concentration methods. Results indicated the highest total phenolic content for stem extract (309.069). All S. ferruginea extracts exhibited antioxidant activity in a dose dependent manner. Stem extract showed capacity to scavenge free radicals and it was also found to chelate Fe2+ better than others. All extracts presented moderate inhibition ability against selected bacteria. The most significant values of MIC and MBC were belonged to the stem extract. These findings suggest that acetone extracts of S. ferruginea, particularly stem extract, are potentially sources of antioxidant compounds.

THE ANTIOXIDANT ACTIVITY AND PHYTOCHEMICAL SCREENING OF ETHANOL EXTRACT, FRACTIONS OF WATER, ETHYL ACETATE AND n-HEXANE FROM MISTLETOE TEA (SCURRULA ATROPURPUREABL. DANS)

“…This assumption in-line with others that majority of antioxidant compounds present in plants are secondary metabolitesphenolic compounds (tannins, flavonoids, and phenolic acids) which exhibit their protective properties through scavenging free radicals [25][26][27]. In addition to phenolics, plants may also contain antioxidant volatile oils, carotenoids, and vitamins [28].…”

Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

“…The analogous results have also been reported in other bioactivities. Scurrula ferruginea stem extract gave a higher potency than leaf extract in antioxidant and antibacterial activity . Moreover, the highest total phenolic content and iron‐chelating ability among the three different plant parts extracts (leaf, stem, and flower) of S. ferruginea were also found to be in the stem.…”

“…In the stems, sugars were the main metabolites that might be because the stem is a vital organ for the plant in accumulating and storing of energy substances . However, the present obtained results indicated that S. ferruginea stems possessed a lower amount of flavonoids and phenolic compounds, which are contradicting with previous studies . It might be due to the different drying methods and extraction solvents employed herein.…”

“…Scurrula ferruginea stem extract gave a higher potency than leaf extract in antioxidant and antibacterial activity. 11 Moreover, the highest total phenolic content and iron-chelating ability among the three different plant parts extracts (leaf, stem, and flower) of S. ferruginea were also found to be in the stem. A number of studies on the other mistletoe genera of Loranthaceae had indicated a strong host-dependency of many tested bioactivities including anti-cancer, 27 antiviral, 2 antioxidant, 28 anti-diabetes, 29,30 decreasing hypertension, 31 and others.…”

“…However, the therapeutic effects of S. ferruginea are still in the exploration stage. For the past few years, besides its reputable usage as an antioxidant, antiviral, antibacterial, and anticancer agent, [9][10][11] S. ferruginea has also been reported to possess remarkable remedies for hypertension, cardiovascular and gastrointestinal disorders. [12][13][14][15][16][17] This plant is also consumed as a daily health protection and enhancement of memory in geriatrics.…”