Total Parenteral Nutrition with Intralipid in Pr Infants Receiving TPN with Heparin

Berkow, Susan E.; Spear, Michael L.; Stahl, Gary E.; Gutman, Alexander B.; Polin, R A; Pereira, Gilberto R.; Olivecrona, Thomas; Hamosh, Paul; Hamosh, Margit

doi:10.1097/00005176-198707000-00016

Cited by 32 publications

(24 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Profiles of the HDL subclass distribution are variable, but the majority of samples have two or more prominent peaks or shoulders within the HDL region. Of the 22 samples, five (5,14,17,19,22) were remarkable in that they had highly unusual distributions. Neonate 5 has a single pronounced peak in the (HDL3b)gge region and a scarcity of material in other subclasses.…”

Section: Nutritional Regimens and Changes In Plasma Lipid Concentrationsmentioning

confidence: 99%

“…the infants (17,19,22) had necrotizing enterocolitis ( Table I). The unusual HDL subclass distribution of these five infants was not related to degree of prematurity since gestational age ranged from 31 to 38 weeks while the remaining 17 ranged from 27 to 42 weeks (Table I).…”

Section: Nutritional Regimens and Changes In Plasma Lipid Concentrationsmentioning

confidence: 99%

“…Plasma lipid concentrations and high density lipoprotein (HDL) sublcass distributions were evaluated in 22 newborn infants nourished with intravenous (iv)-fat. The majority of infants were premature with respiratory distress syndrome.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Effect of Total Parenteral Nutrition with Intravenous Fat on Lipids and High Density Lipoprotein Heterogeneity in Neonates

Forte

Genzel‐Boroviczény²,

Austin

et al. 1989

J Parenter Enteral Nutr

View full text Add to dashboard Cite

Plasma lipid concentrations and high density lipoprotein (HDL) subclass distributions were evaluated in 22 newborn infants nourished with intravenous (iv)-fat. The majority of infants were premature with respiratory distress syndrome. Based on baseline (prior to iv-fat) HDL subclass profiles determined by gradient gel electrophoresis (GGE), infants fell into two classes, one with two or more pronounced peaks within the normal HDL spectrum (group I, 17 subjects) and the other with highly unusual HDL distribution (group II, five subjects). Total plasma cholesterol increased in both groups during low and high fat intravenous feeding. HDL-cholesterol, however, did not change with iv-fat where mean values for groups I and II at baseline, iv-low fat and -high fat were: group I, 31.2 +/- 7.1, 30.0 +/- 8.8, and 36.6 +/- 16.7 mg/dl, respectively; and group II, 20.0 +/- 7.8, 20.2 +/- 7.4, and 19.8 +/- 8.8 mg/dl, respectively. Unlike HDL-cholesterol levels that remained constant with iv-fat, apolipoprotein (apo) AI concentrations increased significantly: group I, 73.0 +/- 11.0, 88.3 +/- 15.9, and 93.1 +/- 21.9 mg/dl, respectively; and group II, 31.8 +/- 10.5, 41.0 +/- 12.8, and 59.3 +/- 18.5 mg/dl, respectively. In group I infants, iv-fat is associated with an increase in larger-sized particles, particularly in the (HDL2b)gge range; in group II there is an increase in (HDL3b)gge and (HDL3c)gge components and a disappearance of particles that fall outside of the size range of normal HDL. In both groups, enteral feeding is associated with a further normalization of HDL subclass distribution. The aberrant GGE profiles and very low apoAI levels of group II infants at baseline were associated with unusual HDL morphology determined by electron microscopy where discoidal structures were prominent. With iv-fat, discoidal particles decline in number while normal spherical structures increase. Prevalence of discoidal HDL at baseline was associated with low concentrations of lecithin:cholesterol acyltransferase (LCAT) (1.12 +/- 0.5 micrograms/ml); with iv-fat this enzyme rose to 1.61 +/- 0.18 micrograms/ml. Increased LCAT is associated with the normalization of HDL morphology. It is likely that iv-fat improves the nutritional status of premature infants, thereby stimulating increased liver synthesis of important proteins, including apoAI and LCAT, associated with HDL metabolism.

show abstract

Section: Nutritional Regimens and Changes In Plasma Lipid Concentrationsmentioning

confidence: 99%

Section: Nutritional Regimens and Changes In Plasma Lipid Concentrationsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Total Parenteral Nutrition with Intravenous Fat on Lipids and High Density Lipoprotein Heterogeneity in Neonates

Forte

Genzel‐Boroviczény²,

Austin

et al. 1989

J Parenter Enteral Nutr

View full text Add to dashboard Cite

show abstract

“…However, while the hypertriglyceridemia is transient [11], the hypercholesterolemia and hyperphospholipidemia are more persistent [11,12]. Since the activities of lipoprotein lipase and hepatic lipase are normally not detected in the circulation, little is understood about the postnatal development of these en zymes in the human.…”

Section: Introductionmentioning

confidence: 99%

Postnatal Development of Plasma-Lipid-Clearing Enzymes (Lipoprotein Lipase, Hepatic Lipase and Lecithin:Cholesterol Acyl Transferase) and Lipid Profiles in Suckling Rats

Mao¹,

Hamosh²

1992

Neonatology

View full text Add to dashboard Cite

We examined the activity of plasma circulating lipoprotein lipase and hepatic lipase, lecithimcholesterol acyl transferase (LCAT), as well as lipid profiles in Sprague-Dawley rats from 1 day until 29 days of age. Plasma lipoprotein lipase activity peaked between ages 5 and 15 days and decreased after weaning, while plasma hepatic lipase activity remained constantly low during the suckling period and increased after weaning. No statistically significant difference in LCAT activity was seen from birth until weaning. Plasma triglycerides, as well as free fatty acids, decreased significantly after birth. Total plasma cholesterol increased during the suckling period and decreased after weaning. HDL cholesterol increased after the first 10 days of life, and free cholesterol remained constant after an initial decrease from birth to the 5th day of life. In conclusion, the enzymes asociated with the metabolism of triglycerides, cholesterols and phospholipids are well developed in the rat shortly after birth.

show abstract

“…Dadurch wird jedoch die Fettutilisation nicht gesteigert. Die gesteigerte Aktivität der Lipoproteinlipase führt zu einem Anstieg der unveresterten Fettsäuren, die u. U. nicht in gleicher Geschwindigkeit verstoffwechselt werden kön− nen[90,91]. Der Lipidstoffwechsel resultiert in einer Lipidperoxidation und der Bildung freier Radikale[92 ± 94].…”

unclassified

13 Neonatologie/Pädiatrie

Fusch¹,

Bauer²,

Böhles³

et al. 2007

Akt Ernähr Med

View full text Add to dashboard Cite

Total Parenteral Nutrition with Intralipid in Pr Infants Receiving TPN with Heparin

Cited by 32 publications

References 0 publications

Effect of Total Parenteral Nutrition with Intravenous Fat on Lipids and High Density Lipoprotein Heterogeneity in Neonates

Effect of Total Parenteral Nutrition with Intravenous Fat on Lipids and High Density Lipoprotein Heterogeneity in Neonates

Postnatal Development of Plasma-Lipid-Clearing Enzymes (Lipoprotein Lipase, Hepatic Lipase and Lecithin:Cholesterol Acyl Transferase) and Lipid Profiles in Suckling Rats

13 Neonatologie/Pädiatrie

Contact Info

Product

Resources

About