Total Pancreatectomy with Islet Auto-Transplantation

Bellin, Melena D.; Ramanathan, Karthik; Chinnakotla, Srinath

doi:10.1016/j.yasu.2023.03.002

Cited by 4 publications

(1 citation statement)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…88 There has been a recent rise in the application and ongoing study of outcomes related to total pancreatectomy and islet auto transplantation. 89 In patients with small duct disease or patients with hereditary pancreatitis, this can result in significant improvements in QOL for patients who typically require frequent hospitalizations for pain, and theoretically, it eliminates the risk of malignant degeneration in those patients with a genetic basis for disease.…”

Section: Endoscopy Versus Surgerymentioning

confidence: 99%

Interventions for Pancreatitis—New Approaches, Knowledge Gaps, and Research Opportunities

Phillips,

Hughes,

Andersen

et al. 2024

Pancreas

View full text Add to dashboard Cite

There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) focused on interventions that might disrupt or perhaps even reverse the natural course of this heterogenous disease, aiming to identify knowledge gaps and research opportunities that might inform future funding initiatives for NIDDK. The breadth and variety of identified active or planned clinical trials traverses the spectrum of the disease and was conceptually grouped for the workshop into behavioral, nutritional, pharmacologic and biologic, and mechanical interventions. Cognitive and other behavioral therapies are proven interventions for pain and addiction, but barriers exist to their use. Whilst a disease specific instrument quantifying pain is now validated, an equivalent is lacking for nutrition - and both face challenges in ease and frequency of administration. Multiple pharmacologic agents hold promise. Ongoing development of Patient Reported Outcome (PRO) measurements can satisfy Investigative New Drug (IND) regulatory assessments. Despite multiple randomized clinical trials demonstrating benefit, great uncertainty remains regarding patient selection, timing of intervention, and type of mechanical intervention (endoscopic versus surgery). Challenges and opportunities to establish beneficial interventions for patients were identified.

show abstract

Section: Endoscopy Versus Surgerymentioning

confidence: 99%