Total pancreatectomy for cholangiocarcinoma of the distal common bile duct associated with lipomatous pseudohypertrophy of pancreas

Jayatunge, Subani Priyangika; Mahendra, G; Siyabalapitiya, Sajith; Siriwardana, R. C.; Liyanage, C.A.H.

doi:10.5348/ijhpd-2015-31-cr-6

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Lipomatous pseudohypertrophy is a rare disease that was first reported by Hantelmann in 1931 [1] . A literature search of the PubMed database, performed by Deniz Altinel (2010), revealed only 37 other cases, worldwide, including cases that were diagnosed by imaging alone [3 – 6 , [12] , [13] , [14] , [15] .…”

Section: Discussionmentioning

confidence: 99%

“…The exact etiology of LPH remains unknown, although various hypotheses have been suggested, including parenchymal atrophy due to ductal obstruction, viral infection, toxin exposure, and congenital anomalies [3 – 6 , [12] , [13] , [14] , [15] . Siegler described this disease as being characterized by (1) an increase in pancreatic size and weight, (2) the near-complete absence of pancreatic exocrine tissue, with the concomitant replacement of pancreatic tissue with normal adipose tissue, and (3) the preservation of pancreatic ducts and islets of Langerhans [2] .…”

Section: Discussionmentioning

confidence: 99%

“…Although the rate of growth and the timeline of fat replacement remain unknown, the condition is believed to take several years to develop [5] . LPH is typically considered to be a benign disease; however, some cases have been associated with cholangiocarcinoma of common bile duct [13] , squamous cell carcinoma [18] , leiomyosarcoma [19] , and carcinoma [20 , 21] .…”

Section: Discussionmentioning

confidence: 99%

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A rare case of lipomatous pseudohypertrophy of the pancreas

Luu

Duc

et al. 2021

Radiology Case Reports

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Lipomatous pseudohypertrophy of the pancreas is a rare disease with unknown etiology, and the pancreas parenchyma is replaced by pancreatic parenchyma by fat tissue. In this article, we aimed to report the case of a 26-year-old male patient admitted to hospital with loss of appetite for 6 months. Abdominal computed tomography (CT) and magnetic resonance imaging (MRI) scans showed diffuse enlargement and fatty replacement over the whole pancreas, with scattered remnants of pancreatic parenchyma. Histologic results defined lipomatous pseudohypertrophy of the pancreas. To summarize, this case report is to put forward this extremely rare presentation and to sensitize clinicians that this entity can be a cause of exocrine pancreatic insufficiency, which requires patient follow-up for the appropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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A rare case of lipomatous pseudohypertrophy of the pancreas

Luu

Duc

et al. 2021

Radiology Case Reports

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“…There are certain types of pancreatectomy including pancreaticoduodenectomy (Whipple procedure), distal pancreatectomy, segmental pancreatectomy and total pancreatectomy [9]. Exocrine and endocrine pancreatic proliferation after partial or total pancreatectomy has been well reported in animal models, but pancreatic proliferation in diabetes has not been documented as yet.…”

Section: Introductionmentioning

confidence: 99%

Pre-Clinical Studies on Diabetes Mellitus Using Partial Pancreatectomy in Swiss Albino Mice

Jana

Mazumder

2018

Int J Pharm Pharm Sci

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Objective: The present study was aimed at the development of partial pancreatectomy in a murine model for diabetes. Methods:Diabetes model was successfully developed by partial pancreatectomy method. In this study, cyclosporine was used for influenced the glycaemic status. Diabetes status was evaluated by fasting blood glucose level (FBG), lipid profile (by estimation of total cholesterol level and HDLlevel), serum amylase and biochemical assay like glutathione estimation. Results:We report here the restoration of euglycaemic status in cyclosporine-induced diabetic in swiss albino mice after 30% pancreatectomy. In this study, Pancreatectomised (partial) group of animals showed a rapid elevation of glycaemic status, starting from 15 th post observational d, but the level of significance decreased gradually from 15 th (P<0.01) to 60 th Conclusion:The biochemical and histopathological evaluations suggest that there is the development of the diabetic model in the pancreatectomized group and diabetes status induced by pancreatectomy is curable to a certain extent due to the regeneration of β-cells.(P<0.05) d. This was probably due to nesidioblastotic activity which shifted the fasting blood glucose level towards normoglycaemic status with β-cells regeneration. Cyclosporine treated a group of mice showed normoglycaemic status throughout the whole experimental period, but the cholesterol level remained significant (P<0.001) till the end of the experimental d. Gradually decrements in glycaemia of the diabetic pancreatectomised animals demonstrate islets neogenesis occurring after the operative activity, leading to normoglycaemic condition, probably attributed to β-cells proliferation.

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Lipomatous pseudohypertrophy of the pancreas mimicking liposarcoma: A case report

Kamimura,

Katsube,

Nishi

et al. 2024

Acta Radiologica Open

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Lipomatous pseudohypertrophy of the pancreas (LPH) is a rare disease in which the pancreatic parenchyma is replaced with mature adipose tissue. It is an idiopathic condition whose diagnosis is made based on histopathological analyses. Herein, we report the case of a 50-year-old male patient with a lipomatous mass in the head of the pancreas on computed tomography for close examination of a renal tumor. We suspected liposarcoma, and laparotomy was performed. However, histological analyses revealed LPH. Several imaging findings of LPH can enable a noninvasive diagnosis and help its clinical approach.

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Total pancreatectomy for cholangiocarcinoma of the distal common bile duct associated with lipomatous pseudohypertrophy of pancreas

Cited by 3 publications

References 8 publications

A rare case of lipomatous pseudohypertrophy of the pancreas

A rare case of lipomatous pseudohypertrophy of the pancreas

Pre-Clinical Studies on Diabetes Mellitus Using Partial Pancreatectomy in Swiss Albino Mice

Lipomatous pseudohypertrophy of the pancreas mimicking liposarcoma: A case report

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