Total Pancreatectomy Combined with Partial Pancreas Autotransplantation for Recurrent Pancreatic Cancer: A Case Report

Extending Indications for Islet Autotransplantation in Pancreatic Surgery

“…The rationale for this assumption is based on the theory of multicentricity of pancreatic cancer and should be revised. Multicentric pancreatic cancer may not be as common as once thought 27 and very few reports of pancreatic carcinoma recurrence in the remnant pancreas after a PD are reported in the literature, 28 except in case of multifocal IPMN. Moreover, pancreatic cancer survival is not improved by total pancreatectomy over partial pancreatectomy 29 and, consequently, in clinical practice the theory of multicentricity of pancreatic cancer does not justify the additional morbidity and lifelong insulin dependence that results from total pancreatectomy.…”

Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report

“…The indication of additional partial pancreas autotransplantation for the second operation in our case was that the recurrent carcinoma showed no microvascular invasion, no lymph node metastasis, and no cancer cells at the surgical margin [1].…”

“…After obtaining informed consent from this patient, we performed completion total pancreatectomy for the locally recurrent pancreatic cancer in the remnant pancreas. We also performed a partial pancreas auto-transplantation with the use of a distal part of the resected pancreas to preserve endocrine function [1]. Final histologic findings showed the recurrent tumor to be an invasive ductal carcinoma consisting of a well-differentiated tubular adenocarcinoma with histopathologic findings similar to those in the primary tumor (pStage IA [pT1, pN0, M0] and R0) [2].…”

“…We performed completion total pancreatectomy for the locally recurrent pancreatic carcinoma. We also performed distal partial pancreas auto-transplantation heterotopically, using a distal part of the resected pancreas to preserve endocrine function [1]. Herein, we report long-term follow-up results about this case.…”

Two Case Reports of Resectable Cancer in the Remnant Pancreas after Pancreatectomy for Invasive Ductal Carcinoma of the Pancreas

“…Despite a few reports of remission by removal of the site of recurrence 2 , complete surgical resection remains the only chance for cure. Review of the current literature revealed 19 cases, including the two present cases, of resectable cancer without low-grade intraductal papillary mucinous neoplasia in the remnant pancreas after pancreatectomy [3][4][5][6][7][8][9][10][11][12][13][14][15] (Table 1). Ten cases were diagnosed as local recurrence, six as second primary cancer, and three were undetermined.…”