Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS

Silva, Francine Cristina da; Rosa, Luciano Pereira; Santos, Gabriel Pinto de Oliveira; Inada, Natália Mayumi; Blanco, Kate Cristina; Araújo, Thalita Santos Dantas; Bagnato, Vanderlei Salvador

doi:10.1080/14787210.2020.1756774

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Additionally, Staphylococcus spp. and Enterobacteria were eliminated from the mouths of patients with AIDS using curcumin and blue light [ 66 ]. In addition to those applications, Song et al [ 67 ] used chlorophyll a and Nicklas et al [ 68 ] used ALA to treat patients with acne vulgaris.…”

Section: Preclinical and Clinical Apdt Studiesmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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Health problems and reduced treatment effectiveness due to antimicrobial resistance have become important global problems and are important factors that negatively affect life expectancy. Antimicrobial photodynamic therapy (APDT) is constantly evolving and can minimize this antimicrobial resistance problem. Reactive oxygen species produced when nontoxic photosensitizers are exposed to light are the main functional components of APDT responsible for microbial destruction; therefore, APDT has a broad spectrum of target pathogens, such as bacteria, fungi, and viruses. Various photosensitizers, including natural extracts, compounds, and their synthetic derivatives, are being investigated. The main limitations, such as weak antimicrobial activity against Gram-negative bacteria, solubility, specificity, and cost, encourage the exploration of new photosensitizer candidates. Many additional methods, such as cell surface engineering, cotreatment with membrane-damaging agents, nanotechnology, computational simulation, and sonodynamic therapy, are also being investigated to develop novel APDT methods with improved properties. In this review, we summarize APDT research, focusing on natural photosensitizers used in in vitro and in vivo experimental models. In addition, we describe the limitations observed for natural photosensitizers and the methods developed to counter those limitations with emerging technologies.

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Section: Preclinical and Clinical Apdt Studiesmentioning

confidence: 99%

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

2021

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“…PDT has several advantages over traditional treatments: it is less invasive, causes fewer side effects than systemic medication, and is more precise in targeting the lesion while preserving normal tissues. Nowadays, PDT therapy has been widely used to treat oral diseases, including leukoplakia [11][12][13][14]. However, existing reports differ in the types of medium, duration of application, light source, and wavelength used, among other factors.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy (PDT) for oral leukoplakia: a systematic review and meta-analysis of single-arm studies examining efficacy and subgroup analyses

Zhang

Gao

Wang³

2023

BMC Oral Health

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Objective This study aims to evaluate the efficacy of photodynamic therapy (PDT) in the treatment of oral leukoplakia and explore the subgroup factors that may influence its effectiveness. Methods A systematic search was conducted in PubMed, Embase, the Cochrane Library, and Web of Science databases to identify relevant studies. Meta-analysis was performed using Stata15.0 software. Cochran’s Q test and I2 statistics were used to evaluate heterogeneity, egger’s test was used to evaluate publication bias. Results The analysis of 17 studies included in this study suggests that PDT may be effective in achieving complete response (CR) [ES = 0.50, 95%CI: (0.33,0.66)], partial response (PR) [ES = 0.42, 95%CI: (0.27,0.56)], no response (NR) [ES = 0.19, 95%CI: (0.11,0.27)]in patients with oral leukoplakia. The recurrence rate was also evaluated [ES = 0.13, 95%CI: (0.08,0.18)]. Subgroup analysis showed that various factors such as light source, wavelength, medium, duration of application, clinical and pathological diagnosis classification influenced efficacy of PDT. The lesion areas of the leukoplakia after treatment were reduced by 1.97cm2 compared with those before treatment. Conclusion Our findings show that PDT is a viable treatment for oral leukoplakia. However, the effectiveness of the therapy may depend on several factors, as suggested by our subgroup analyses. (Registration no. CRD42023399848 in Prospero, 26/02/2023)

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“…Regarding the antimicrobial e cacy of aPDT, many studies have shown promising results, often reaching inactivation rates of more than 5 log10 CFU, which is understood as a disinfectant effect according to infection control guidelines. Data suggest that photodynamic therapy is potentially effective against bacterial, viral, fungal and protozoal infections [19][20][21][22]. The in vitro mechanism of action described in some studies shows that this therapy induces the generation of reactive oxygen (ROS) and nitrogen species, which effectively damage a variety of fungal cell structures and induce cell death [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Comparative Study about the Efficacy of Low Level Laser Therapy and Curcumin Antimicrobial Photodynamic Therapy as a Coadjuvant Treatment of Oral Mucositis in Oncologic Patients:Antimicrobial, Analgesic and Degree Alteration Effect.

Andrade

Reis

Rosa

et al. 2021

Preprint

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INTRODUCTION: As conventional treatments currently available for mucositis are not considerably effective,there is a need to implement an adjuvant protocol for the treatment of oral mucositis in patients undergoing radiotherapy and chemotherapy.PURPOSE: To evaluate the effect of Low Level Laser Therapy and Antimicrobial Photodynamic Therapy mediated by curcumin and blue LED as an adjunct treatment of oral mucositis foroncology patients using chemotherapy and or radiotherapy.METHODS: Clinical, randomized study, in a single location, in an oncology service of a general hospital, with a total of 30 patients (over 18 years old) with stable oral mucosa lesions in the process of Chemotherapy and or Radiotherapy. The patients were divided into 3 groups: Control group (treated with nystatin), LLLT group (treated with Low Level Laser Therapy), and the aPDT group (treated with 450 nm blue LED and curcumin photosensitizer).RESULTS: The results showed, by means of intra-group comparisons, that the two experimental treatments promoted yeast reduction of the genus Candida in the last two evaluations (21 days and 30 days), but not in the first two evaluations (7 days and 14 days). The intra-group comparisons showed that the Control and aPDT group showed a significant difference in the degree of mucositis over the four evaluations performed, with the results pointing out that the mucositis worsened in the control group from the 14th day, while reduced in the aPDT group from the 21st day of treatment.CONCLUSION: A reduction in the degree of mucositis and pain score was observed in the LLLT and aPDT groups, with the aPDT group standing out when presenting early clinical improvement in relation to the LLLT group and the control group, thus emphasizing its effectiveness within the desired aspects. Regarding the antimicrobial effect, aPDT showed a greater reduction of yeasts of the genus Candida in the tested parameters.

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Total mouth photodynamic therapy mediated by blue led and curcumin in individuals with AIDS

Cited by 9 publications

References 29 publications

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Natural Photosensitizers in Antimicrobial Photodynamic Therapy

Photodynamic therapy (PDT) for oral leukoplakia: a systematic review and meta-analysis of single-arm studies examining efficacy and subgroup analyses

Comparative Study about the Efficacy of Low Level Laser Therapy and Curcumin Antimicrobial Photodynamic Therapy as a Coadjuvant Treatment of Oral Mucositis in Oncologic Patients:Antimicrobial, Analgesic and Degree Alteration Effect.

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